Methyl 3-methyl-4-oxopentanoate

Base Information

• Chemical Name: Methyl 3-methyl-4-oxopentanoate
• CAS No.: 25234-83-7
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.17
• Mol file: 25234-83-7.mol

Synonyms:Levulinicacid, 3-methyl-, methyl ester (6CI,8CI); Methyl 3-methyl-4-oxopentanoate

Chemical Property of Methyl 3-methyl-4-oxopentanoate

Chemical Property:

• Vapor Pressure: 0.332mmHg at 25°C
• Refractive Index: 1.4312 (589.3 nm 20℃)
• Boiling Point: 200°C at 760 mmHg
• Flash Point: 73.7°C
• PSA: 43.37000
• Density: 0.993g/cm³
• LogP: 0.77460

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-methyl-4-oxopentanoate

There total 23 articles about Methyl 3-methyl-4-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 3-methyllevulinic acid (6628-79-1) → methyl 3-methyl-4-oxopentanoate (25234-83-7)

Guidance literature:

With sulfuric acid; at 50 ℃; for 5h;

DOI:10.1016/j.tet.2019.130760

Reference yield: 85.0%

methyl crotonate (623-43-8,4358-59-2,18707-60-3,130981-57-6) + 1-(trimethylsilyl)ethanone (13411-48-8) → methyl 3-methyl-4-oxopentanoate (25234-83-7)

Guidance literature:

With 4-((7-phenyl-6H-naphthochromen-3-yl)ethynyl)benzonitrile; In methanol; for 15h; Reagent/catalyst; Irradiation;

DOI:10.1002/anie.201912455

Reference yield: 81.0%

3-hydroxy-3-methyl-4-oxo-valeric acid methyl ester → methyl 3-methyl-4-oxopentanoate (25234-83-7)

Guidance literature:

With potassium acetate; L-proline; In dimethyl sulfoxide; at 130 ℃; for 8h;

DOI:10.1039/c9sc02543j

upstream raw materials:

methanol

3-methyllevulinic acid

diazomethane

methyl crotonate

Refernces

• 1、 Lin, Weimin,McGinness, Robert J.,Wilson, Emerald C.,Zercher, Charles K.. "Formation of β-substituted γ-keto esters via zinc carbenoid mediated chain extension". . p. 2404 - 2408. Retrieved 2007.
• 2、 Rakshit, Devajyoti,Thomas, Susan E.. "Addition of alkyllithium and Grignard reagents to tetracarbonyliron complexes of α,β-unsaturated esters". . p. C3 - C5. Retrieved 1987.
• 3、 Mateos, Javier,Rigodanza, Francesco,Vega-Pe?aloza, Alberto,Sartorel, Andrea,Natali, Mirco,Bortolato, Tommaso,Pelosi, Giorgio,Companyó, Xavier,Bonchio, Marcella,Dell'Amico, Luca. "Naphthochromenones: Organic Bimodal Photocatalysts Engaging in Both Oxidative and Reductive Quenching Processes". supporting information. p. 1302 - 1312. Retrieved 2019/11/26.