ethyl 2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carboxylate

Base Information

Chemical Name:ethyl 2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carboxylate
CAS No.:173033-18-6
Molecular Formula:C₂₆H₂₃NO₈
Molecular Weight:477.471
Hs Code.:

Synonyms:ethyl 2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carboxylate

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Chemical Property of ethyl 2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carboxylate

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Technology Process of ethyl 2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carboxylate

There total 4 articles about ethyl 2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 62427-71-8,56862-58-9
(E)-3-[3-methoxy-4-(methoxymethoxy)phenyl]acrylaldehyde

: 173033-17-5
ethyl 2-diethoxyphosphorylmethyl-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carboxylate

: 173033-18-6
ethyl 2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carboxylate

Guidance literature:: With 4 A molecular sieve; sodium hydride; In tetrahydrofuran; at 20 ℃; for 17h;

Reference yield:

: 30192-51-9
ethyl 8-amino-7-hydroxy-4-oxo-4H-1-benzopyran-2-carboxylate

: 173033-18-6
ethyl 2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / NaHCO₃ / acetone / 2 h / 20 °C

2: 84 percent / ethyl polyphosphate / 1,2-dichloro-ethane / 4 h / Heating

3: 93 percent / 4 h / 140 °C

4: 83 percent / NaH; molecular sieves (4 Angstroem) / tetrahydrofuran / 17 h / 20 °C

With ethyl phosphate; 4 A molecular sieve; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; 1,2-dichloro-ethane; acetone; 1: chloroacetylation / 2: Cyclization / 3: Substitution / 4: Condensation;

Reference yield:

: 32278-24-3
ethyl 8-N-(chloroacetyl)amino-7-hydroxy-4-oxo-4H-1-benzopyran-2-carboxylate

: 173033-18-6
ethyl 2-[(1E,3E)-4-(3-methoxy-4-methoxymethoxyphenyl)-1,3-butadienyl]-6-oxo-6H-pyrano[2,3-e]benzoxazole-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / ethyl polyphosphate / 1,2-dichloro-ethane / 4 h / Heating

2: 93 percent / 4 h / 140 °C

3: 83 percent / NaH; molecular sieves (4 Angstroem) / tetrahydrofuran / 17 h / 20 °C

With ethyl phosphate; 4 A molecular sieve; sodium hydride; In tetrahydrofuran; 1,2-dichloro-ethane; 1: Cyclization / 2: Substitution / 3: Condensation;