1-tert-butyl 2-ethyl 5-chloro-3-(1-phenylvinyl)-1H-indole-1,2-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 2-ethyl 5-chloro-3-(1-phenylvinyl)-1H-indole-1,2-dicarboxylate
CAS No.:1374964-67-6
Molecular Formula:C₂₄H₂₄ClNO₄
Molecular Weight:425.912
Hs Code.:

Synonyms:1-tert-butyl 2-ethyl 5-chloro-3-(1-phenylvinyl)-1H-indole-1,2-dicarboxylate

Suppliers and Price of 1-tert-butyl 2-ethyl 5-chloro-3-(1-phenylvinyl)-1H-indole-1,2-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-tert-butyl 2-ethyl 5-chloro-3-(1-phenylvinyl)-1H-indole-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-tert-butyl 2-ethyl 5-chloro-3-(1-phenylvinyl)-1H-indole-1,2-dicarboxylate

There total 1 articles about 1-tert-butyl 2-ethyl 5-chloro-3-(1-phenylvinyl)-1H-indole-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1374964-63-2
1-tert-butyl 2-ethyl 3-benzoyl-5-chloro-1H-indole-1,2-dicarboxylate

: 27200-84-6
methyl triphenylphosphonium bromide

: 1374964-71-2
ethyl 5-chloro-3-(1-phenylvinyl)-1H-indole-2-carboxylate

: 1374964-67-6
1-tert-butyl 2-ethyl 5-chloro-3-(1-phenylvinyl)-1H-indole-1,2-dicarboxylate

Guidance literature:: methyl triphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 0.333333h; Inert atmosphere;

1-tert-butyl 2-ethyl 3-benzoyl-5-chloro-1H-indole-1,2-dicarboxylate; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ml3000462

Reference yield: 37.0%

: 75-11-6
diiodomethane

: 1374964-67-6
1-tert-butyl 2-ethyl 5-chloro-3-(1-phenylvinyl)-1H-indole-1,2-dicarboxylate

: 1374964-75-6
ethyl 5-chloro-3-(1-phenylcyclopropyl)-1H-indole-2-carboxylate

Guidance literature:: diiodomethane; With diethylzinc; trifluoroacetic acid; In dichloromethane; for 0.333333h; Inert atmosphere;

1-tert-butyl 2-ethyl 5-chloro-3-(1-phenylvinyl)-1H-indole-1,2-dicarboxylate; In dichloromethane; for 2h; Inert atmosphere;
DOI:10.1021/ml3000462

Reference yield:

: 1374964-67-6
1-tert-butyl 2-ethyl 5-chloro-3-(1-phenylvinyl)-1H-indole-1,2-dicarboxylate

: 1374964-57-4
5-chloro-3-(1-phenylcyclopropyl)-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylzinc; trifluoroacetic acid / dichloromethane / 0.33 h / Inert atmosphere

1.2: 2 h / Inert atmosphere

2.1: potassium hydroxide / ethanol; water / 2 h / 80 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; diethylzinc; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml3000462