2-(2-(2-(2-((4-(((tert-butoxycarbonyl)amino)methyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

Base Information

Chemical Name:2-(2-(2-(2-((4-(((tert-butoxycarbonyl)amino)methyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid
CAS No.:1566584-42-6
Molecular Formula:C₂₇H₂₉F₃N₄O₄
Molecular Weight:530.547
Hs Code.:

Synonyms:2-(2-(2-(2-((4-(((tert-butoxycarbonyl)amino)methyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

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Chemical Property of 2-(2-(2-(2-((4-(((tert-butoxycarbonyl)amino)methyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

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Technology Process of 2-(2-(2-(2-((4-(((tert-butoxycarbonyl)amino)methyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

There total 10 articles about 2-(2-(2-(2-((4-(((tert-butoxycarbonyl)amino)methyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1566584-41-5
methyl 2-(2-(2-(2-((4-(((tert-butoxycarbonyl)amino)methyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

: 1566584-42-6
2-(2-(2-(2-((4-(((tert-butoxycarbonyl)amino)methyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

: 4403-71-8
(4-aminomethyl)aniline

: 1566584-42-6
2-(2-(2-(2-((4-(((tert-butoxycarbonyl)amino)methyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: zinc(II) chloride / tert-butyl alcohol; 1,2-dichloro-ethane; diethyl ether / 0.33 h / 20 °C

2.2: 20 °C

3.1: copper(l) iodide; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 0.08 h

3.2: 0.33 h / 120 °C / Microwave irradiation

4.1: triethylamine; palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

With copper(l) iodide; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; triethylamine; triphenylphosphine; zinc(II) chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1566584-42-6
2-(2-(2-(2-((4-(((tert-butoxycarbonyl)amino)methyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: zinc(II) chloride / tert-butyl alcohol; 1,2-dichloro-ethane; diethyl ether / 0.33 h / 20 °C

2.2: 20 °C

3.1: copper(l) iodide; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 0.08 h

3.2: 0.33 h / 120 °C / Microwave irradiation

4.1: triethylamine; palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

With copper(l) iodide; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; triethylamine; triphenylphosphine; zinc(II) chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;