(3S,4S,5R)-1-benzyl-5-hydroxymethyl-3,4-isopropylidenedioxy-2-pyrrolidinone

Base Information

Chemical Name:(3S,4S,5R)-1-benzyl-5-hydroxymethyl-3,4-isopropylidenedioxy-2-pyrrolidinone
CAS No.:132430-66-1
Molecular Formula:C₁₅H₁₉NO₄
Molecular Weight:277.32
Hs Code.:

Synonyms:(3S,4S,5R)-1-benzyl-5-hydroxymethyl-3,4-isopropylidenedioxy-2-pyrrolidinone

Suppliers and Price of (3S,4S,5R)-1-benzyl-5-hydroxymethyl-3,4-isopropylidenedioxy-2-pyrrolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (3S,4S,5R)-1-benzyl-5-hydroxymethyl-3,4-isopropylidenedioxy-2-pyrrolidinone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3S,4S,5R)-1-benzyl-5-hydroxymethyl-3,4-isopropylidenedioxy-2-pyrrolidinone

There total 5 articles about (3S,4S,5R)-1-benzyl-5-hydroxymethyl-3,4-isopropylidenedioxy-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 132489-30-6
(3S,4S,5R)-1-benzyl-5-benzyloxymethyl-3,4-isopropylidenedioxy-2-pyrrolidinone

: 132430-66-1
(3S,4S,5R)-1-benzyl-5-hydroxymethyl-3,4-isopropylidenedioxy-2-pyrrolidinone

Guidance literature:: With hydrogen; palladium; In ethanol; for 13h; under 760 Torr; Ambient temperature;
DOI:10.1248/cpb.38.2712

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 132430-66-1
(3S,4S,5R)-1-benzyl-5-hydroxymethyl-3,4-isopropylidenedioxy-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) THF, DMF, RT, 1h, 2.) RT, 20h

2: 1.) lithium diisopropylamide / 1.) THF, hexane, -78 deg C, 40 min, 2.) THF, -78 deg C, 5 min

3: 81 percent / 30percent H₂O₂ / ethyl acetate / 0.5 h / 15 - 20 °C

4: 11 percent / OsO₄, N-methylmorpholine N-oxide*H₂O / acetone; H₂O / 14 h / Ambient temperature

5: 90 percent / p-TsOH / acetone / 2 h / Ambient temperature

6: 86 percent / H₂ / Pd black / ethanol / 13 h / 760 Torr / Ambient temperature

With osmium(VIII) oxide; hydrogen; dihydrogen peroxide; sodium hydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; lithium diisopropyl amide; palladium; In ethanol; water; ethyl acetate; acetone;
DOI:10.1248/cpb.38.2712

Reference yield:

: 113571-61-2
(S)-1-benzyl-5-benzyloxymethyl-2-oxo-3-pyrroline

: 132430-66-1
(3S,4S,5R)-1-benzyl-5-hydroxymethyl-3,4-isopropylidenedioxy-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: OsO₄

2: p-TsOH / acetone

3: H₂ / Pd black / methanol

With hydrogen; toluene-4-sulfonic acid; osmium(VIII) oxide; palladium; In methanol; acetone;
DOI:10.1248/cpb.35.2140