N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline hydrochloride

Base Information

Chemical Name:N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline hydrochloride
CAS No.:1352610-25-3
Molecular Formula:C₂₂H₁₈FN₇*ClH
Molecular Weight:435.891
Hs Code.:

Synonyms:N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline hydrochloride

Suppliers and Price of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline hydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline hydrochloride

There total 7 articles about N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1352608-82-2
N-((4-([1,2,4]triazolo[1,5-a]pyridine-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline

: 1352610-25-3
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 0 - 20 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: C₂₂H₁₆FN₇

: 1352610-25-3
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2: hydrogenchloride / dichloromethane; diethyl ether / 0.08 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 356560-84-4
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione

: 1352610-25-3
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium acetate / methanol; tert-butyl methyl ether; water / 4 h / 20 °C

2: hydrogenchloride / water / 4 h / 70 °C

3: acetic acid / 1,2-dichloro-ethane / 2 h / Reflux; Inert atmosphere

4: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

5: hydrogenchloride / dichloromethane; diethyl ether / 0.08 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; ammonium acetate; acetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; tert-butyl methyl ether; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022