1,2,4-Trimethoxy-3-prop-2-enylbenzene

Base Information

• Chemical Name: 1,2,4-Trimethoxy-3-prop-2-enylbenzene
• CAS No.: 5353-16-2
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.257
• DSSTox Substance ID: DTXSID301269557
• Nikkaji Number: J510.880B
• Mol file: 5353-16-2.mol

Synonyms:5353-16-2;DTXSID301269557;1,2,4-Trimethoxy-3-(2-propen-1-yl)benzene

Chemical Property of 1,2,4-Trimethoxy-3-prop-2-enylbenzene

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 208.109944368
• Heavy Atom Count: 15
• Complexity: 193

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C(=C(C=C1)OC)OC)CC=C

Technology Process of 1,2,4-Trimethoxy-3-prop-2-enylbenzene

There total 4 articles about 1,2,4-Trimethoxy-3-prop-2-enylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2,3,6-trimethoxybenzoic acid (60241-74-9) + 3-chloroprop-1-ene (107-05-1) → 2-allyl-1,3,4-trimethoxybenzene (5353-16-2)

Guidance literature:

With copper(I) oxide; palladium diacetate; dimethyl sulfoxide; silver carbonate; In toluene; at 110 ℃; for 2h; chemoselective reaction;

DOI:10.1039/c0ob00696c

Reference yield: 35.0%

1,2,4-trimethoxy-benzene (135-77-3) + allyl bromide (106-95-6) → 2-allyl-1,3,4-trimethoxybenzene (5353-16-2)

Guidance literature:

1,2,4-trimethoxy-benzene; With n-butyllithium; In diethyl ether; hexane; at -10 - 20 ℃; Inert atmosphere;

allyl bromide; In diethyl ether; hexane; at -10 ℃; Inert atmosphere;

DOI:10.1080/00397910902805598

Reference yield:

3,4-dimethoxyphenol (2033-89-8) + allyl bromide (106-95-6) + dimethyl sulfate (77-78-1) → 1-allyl-2,4,5-trimethoxybenzene (5353-15-1) + 2-allyl-1,3,4-trimethoxybenzene (5353-16-2)

Guidance literature:

Multistep reaction;

DOI:10.1016/0031-9422(92)80425-E

upstream raw materials:

3,4-dimethoxyphenol

allyl bromide

dimethyl sulfate

2-(allyloxy)-1,4-dimethoxybenzene

Downstream raw materials:

cis-2,3,6-Trimethoxy-1-propenyl-benzol

(E)-1,2,4-trimethoxy-3-(prop-1-en-1-yl)benzene

2,3-Dihydro-4,7-dimethoxy-2-methylbenzofuran

1-(2'-Bromopropyl)-2,3,6-trimethoxybenzene