1-((2R,3aS,7R,7aS)-7-(benzyloxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-((2R,3aS,7R,7aS)-7-(benzyloxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
CAS No.:1352234-76-4
Molecular Formula:C₂₀H₂₄N₂O₅
Molecular Weight:372.421
Hs Code.:

Synonyms:1-((2R,3aS,7R,7aS)-7-(benzyloxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-((2R,3aS,7R,7aS)-7-(benzyloxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

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Technology Process of 1-((2R,3aS,7R,7aS)-7-(benzyloxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

There total 21 articles about 1-((2R,3aS,7R,7aS)-7-(benzyloxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1352234-75-3
C

: 1352234-76-4
1-((2R,3aS,7R,7aS)-7-(benzyloxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; Reflux;

Reference yield:

: 1352234-70-8
1,2-O-isopropylidene-5-O-benzyl-6-deoxy-3,6-C-divinyl-α-D-gulofuranose

: 1352234-76-4
1-((2R,3aS,7R,7aS)-7-(benzyloxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: dowex 50W₈X / 1,4-dioxane; water / 50 °C

1.2: 0 - 25 °C

2.1: N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate / acetonitrile / 0 - 83 °C

3.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / Reflux

4.1: hydrogen / palladium 10% on activated carbon / methanol

5.1: potassium carbonate; methanol

6.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / Reflux

With methanol; N,O-bis-(trimethylsilyl)-acetamide; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; hydrogen; tri-n-butyl-tin hydride; potassium carbonate; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1352234-73-1
C₂₂H₂₄N₂O₇

: 1352234-76-4
1-((2R,3aS,7R,7aS)-7-(benzyloxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol

2: potassium carbonate; methanol

3: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / Reflux

With methanol; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; potassium carbonate; palladium 10% on activated carbon; In methanol; toluene;