N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methyl-2-methyleneheptanamide

Base Information

Chemical Name:N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methyl-2-methyleneheptanamide
CAS No.:1380325-30-3
Molecular Formula:C₂₃H₂₉NO₂
Molecular Weight:351.489
Hs Code.:

Synonyms:N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methyl-2-methyleneheptanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methyl-2-methyleneheptanamide

Chemical Property:

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Technology Process of N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methyl-2-methyleneheptanamide

There total 4 articles about N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methyl-2-methyleneheptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 4436-84-4
2-methyleneheptanoic acid

: 550-58-3,20616-51-7,20616-52-8,46797-67-5,53176-60-6,54852-85-6,75196-48-4,90365-73-4
(1R,2S)-1,2-diphenyl-2-(N-methyl)aminoethanol

: 1380325-30-3
N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methyl-2-methyleneheptanamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 23 ℃; for 15h; Inert atmosphere;
DOI:10.1002/anie.201200370

Reference yield:

: 530-36-9,3764-63-4,13286-63-0,23190-16-1,23190-17-2,23364-44-5,23412-95-5,39664-87-4,88082-66-0
(1S,2S)-2-amino-1,2-diphenylethanol

: 1380325-30-3
N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methyl-2-methyleneheptanamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / 2.5 h / -40 - 23 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 22.17 h / 0 - 23 °C / Inert atmosphere

3: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 23 °C / Inert atmosphere

With lithium aluminium tetrahydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/anie.201200370

Reference yield:

: 23190-16-1
(1R,2S)-2-Amino-1,2-diphenylethanol

: 1380325-30-3
N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methyl-2-methyleneheptanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3 h / 23 - 150 °C / Inert atmosphere

2.1: thionyl chloride / 0.67 h / 0 - 23 °C / Inert atmosphere

2.2: 2 h / 120 °C / Cooling with ice; Inert atmosphere

3.1: tetrahydrofuran; diethyl ether / 2.5 h / -40 - 23 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 22.17 h / 0 - 23 °C / Inert atmosphere

5.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 23 °C / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/anie.201200370