tert-butyl N-[carbamoyl(phenyl)methyl]carbamate

Base Information

Chemical Name:tert-butyl N-[carbamoyl(phenyl)methyl]carbamate
CAS No.:437768-38-2
Molecular Formula:C₁₃H₁₈N₂O₃
Molecular Weight:250.298
Hs Code.:
DSSTox Substance ID:DTXSID301153673
Nikkaji Number:J2.119.467K

Synonyms:tert-butyl N-[carbamoyl(phenyl)methyl]carbamate;tert-Butyl 2-amino-2-oxo-1-phenylethylcarbamate;437768-38-2;tert-butyl N-(2-amino-2-oxo-1-phenylethyl)carbamate;SCHEMBL3212586;DTXSID301153673;AKOS015954821;EN300-190875;Carbamic acid, (2-amino-2-oxo-1-phenylethyl)-, 1,1-dimethylethyl ester

Suppliers and Price of tert-butyl N-[carbamoyl(phenyl)methyl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl N-[carbamoyl(phenyl)methyl]carbamate

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:250.13174244
Heavy Atom Count:18
Complexity:304

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(C1=CC=CC=C1)C(=O)N

Technology Process of tert-butyl N-[carbamoyl(phenyl)methyl]carbamate

There total 3 articles about tert-butyl N-[carbamoyl(phenyl)methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 541-41-3
chloroformic acid ethyl ester

: 2900-27-8,3601-66-9,14675-97-9,33125-05-2
2-(tert-butoxycarbonylamino)-2-phenylacetic acid

: 437768-38-2
(S)-tert-butyl 2-amino-2-oxo-1-phenylethylcarbamate

Guidance literature:: chloroformic acid ethyl ester; 2-(tert-butoxycarbonylamino)-2-phenylacetic acid; With TEA; In tetrahydrofuran; at -10 ℃; for 0.5h;

With ammonia; In tetrahydrofuran; cooling;
DOI:10.1016/j.bmcl.2006.09.095

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 437768-38-2
(S)-tert-butyl 2-amino-2-oxo-1-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 67 percent / aq. NaOH / dioxane / 12 h / 20 °C

2.1: TEA / tetrahydrofuran / 0.5 h / -10 °C

2.2: 90 percent / NH₃ / tetrahydrofuran / cooling

With sodium hydroxide; TEA; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.bmcl.2006.09.095

Reference yield:

: 2835-06-5
phenylglycin

: 437768-38-2
(S)-tert-butyl 2-amino-2-oxo-1-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 67 percent / aq. NaOH / dioxane / 12 h / 20 °C

2.1: TEA / tetrahydrofuran / 0.5 h / -10 °C

2.2: 90 percent / NH₃ / tetrahydrofuran / cooling

With sodium hydroxide; TEA; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.bmcl.2006.09.095