1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzylidene)piperazin-2-one

Base Information

Chemical Name:1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzylidene)piperazin-2-one
CAS No.:151692-08-9
Molecular Formula:C₂₄H₂₈N₂O₅
Molecular Weight:424.497
Hs Code.:

Synonyms:1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzylidene)piperazin-2-one

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Chemical Property of 1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzylidene)piperazin-2-one

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Technology Process of 1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzylidene)piperazin-2-one

There total 8 articles about 1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzylidene)piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 151692-05-6
4-benzyl-1-tert-butoxycarbonyl-3-(3-methoxybenzylidene)piperazine-2,5-dione

: 151692-08-9
1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzylidene)piperazin-2-one

Guidance literature:: With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; hexane; at 0 ℃; for 1h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 151692-08-9
1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzylidene)piperazin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 22 percent / NEt₃, 4-dimethylaminopyridine / pyridine / 12 h / 60 °C

2: 64 percent / potassium fluoride-alumina / 0.25 h / Irradiation; microwaves

3: 1) NaH / 1) DMF, 0 deg C, 30 min, 2) DMF, rt, 2 h

4: 66 percent / lithium tri-tert-butoxyaluminiumhydride / tetrahydrofuran; hexane / 1 h / 0 °C

With dmap; potassium fluoride on basic alumina; sodium hydride; lithium tri-t-butoxyaluminum hydride; triethylamine; In tetrahydrofuran; pyridine; hexane;

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 151692-08-9
1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzylidene)piperazin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / potassium tert-butoxide / dimethylformamide; 2-methyl-propan-2-ol / 6 h / Ambient temperature

2: 1) NaH / 1) DMF, 0 deg C, 30 min, 2) DMF, rt, 2 h

3: 88 percent / N₂H₄*H₂O / dimethylformamide / 1 h / Ambient temperature

4: 88 percent / NEt₃, 4-dimethylaminopyridine / CH₂Cl₂ / 1 h / Ambient temperature

5: 66 percent / lithium tri-tert-butoxyaluminiumhydride / tetrahydrofuran; hexane / 1 h / 0 °C

With dmap; potassium tert-butylate; sodium hydride; hydrazine hydrate; lithium tri-t-butoxyaluminum hydride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;