4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoic acid

Base Information

Chemical Name:4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoic acid
CAS No.:1391464-81-5
Molecular Formula:C₂₄H₂₆ClN₃O₅
Molecular Weight:471.941
Hs Code.:

Synonyms:4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoic acid

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Chemical Property of 4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoic acid

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Technology Process of 4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoic acid

There total 11 articles about 4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1391464-81-5
4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; methanol / water / 4 h / 34 - 70 °C

1.2: 20 °C

2.1: sulfuric acid / methanol / 24 h / Reflux

3.1: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾ / water; tetrahydrofuran / 3 h / 85 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; N-benzyloxycarbonyl-hydrazine / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 4 h / 20 - 110 °C

5.1: trifluoroacetic acid / dichloromethane / 2.67 h / 0 - 20 °C

With methanol; N-benzyloxycarbonyl-hydrazine; sulfuric acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 42521-10-8
2-chloro-6-methoxyisonicotinic acid methyl ester

: 1391464-81-5
4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾ / water; tetrahydrofuran / 3 h / 85 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; N-benzyloxycarbonyl-hydrazine / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 4 h / 20 - 110 °C

3.1: trifluoroacetic acid / dichloromethane / 2.67 h / 0 - 20 °C

With N-benzyloxycarbonyl-hydrazine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;