tert-butyl 4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoate

Base Information

Chemical Name:tert-butyl 4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoate
CAS No.:1391465-59-0
Molecular Formula:C₂₈H₃₄ClN₃O₅
Molecular Weight:528.048
Hs Code.:

Synonyms:tert-butyl 4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoate

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Chemical Property of tert-butyl 4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoate

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Technology Process of tert-butyl 4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoate

There total 11 articles about tert-butyl 4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1391465-59-0
tert-butyl 4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; methanol / water / 4 h / 34 - 70 °C

1.2: 20 °C

2.1: sulfuric acid / methanol / 24 h / Reflux

3.1: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾ / water; tetrahydrofuran / 3 h / 85 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; N-benzyloxycarbonyl-hydrazine / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 4 h / 20 - 110 °C

With methanol; N-benzyloxycarbonyl-hydrazine; sulfuric acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 42521-10-8
2-chloro-6-methoxyisonicotinic acid methyl ester

: 1391465-59-0
tert-butyl 4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾ / water; tetrahydrofuran / 3 h / 85 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; N-benzyloxycarbonyl-hydrazine / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 4 h / 20 - 110 °C

With N-benzyloxycarbonyl-hydrazine; N-ethyl-N,N-diisopropylamine; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1262413-92-2
2-cyclopentyl-6-methoxyisonicotinic acid methyl ester

: 1391465-58-9
tert-butyl 4-(2-chloro-4-(N-hydroxycarbamimidoyl)-6-methylphenoxy)butanoate

: 1391465-59-0
tert-butyl 4-(2-chloro-4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)butanoate

Guidance literature:: 2-cyclopentyl-6-methoxyisonicotinic acid methyl ester; With N-benzyloxycarbonyl-hydrazine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

tert-butyl 4-(2-chloro-4-(N-hydroxycarbamimidoyl)-6-methylphenoxy)butanoate; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; at 20 - 110 ℃; for 4h;