5-Pyrimidinecarboxamide, N-(1-benzyl-4-piperidyl)-4-methoxy-

Base Information

Chemical Name:5-Pyrimidinecarboxamide, N-(1-benzyl-4-piperidyl)-4-methoxy-
CAS No.:72412-47-6
Molecular Formula:C₁₈H₂₂N₄O₂
Molecular Weight:326.398
Hs Code.:
DSSTox Substance ID:DTXSID10222711
Nikkaji Number:J70.342G
Wikidata:Q83101027
Mol file:72412-47-6.mol

Synonyms:72412-47-6;BRN 5606855;N-(1-Benzyl-4-piperidyl)-4-methoxy-5-pyrimidinecarboxamide;5-Pyrimidinecarboxamide, N-(1-benzyl-4-piperidyl)-4-methoxy-;DTXSID10222711;LS-134781

Suppliers and Price of 5-Pyrimidinecarboxamide, N-(1-benzyl-4-piperidyl)-4-methoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 5-Pyrimidinecarboxamide, N-(1-benzyl-4-piperidyl)-4-methoxy-

Chemical Property:

Vapor Pressure:7.23E-11mmHg at 25°C
Boiling Point:518.8°C at 760 mmHg
Flash Point:267.6°C
PSA：70.84000
Density:1.23g/cm³
LogP:2.39230
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:326.17427596
Heavy Atom Count:24
Complexity:393

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=NC=NC=C1C(=O)NC2CCN(CC2)CC3=CC=CC=C3

Technology Process of 5-Pyrimidinecarboxamide, N-(1-benzyl-4-piperidyl)-4-methoxy-

There total 3 articles about 5-Pyrimidinecarboxamide, N-(1-benzyl-4-piperidyl)-4-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84332-00-3
methyl 4-methoxypyrimidine-5-carboxylate

: 72412-47-6
4-Methoxy-pyrimidine-5-carboxylic acid (1-benzyl-piperidin-4-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / methanol; H₂O / 1 h / 65 °C

2: 1.) triethylamine, ethylchloroformate / 1.) THF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 41103-17-7
ethyl 4-chloropyrimidine-5-carboxylate

: 72412-47-6
4-Methoxy-pyrimidine-5-carboxylic acid (1-benzyl-piperidin-4-yl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / sodium / Ambient temperature

2: NaOH / methanol; H₂O / 1 h / 65 °C

3: 1.) triethylamine, ethylchloroformate / 1.) THF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 50541-93-0
4-amino-1-benzylpiperidine

: 72411-89-3
4-methoxy-5-pyrimidinyl carboxylic acid

: 72412-47-6
4-Methoxy-pyrimidine-5-carboxylic acid (1-benzyl-piperidin-4-yl)-amide

Guidance literature:: With chloroformic acid ethyl ester; triethylamine; Yield given. Multistep reaction; 1.) THF, 0 deg C, 30 min, 2.) room temp. overnight;