2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneacetonitrile

Base Information

Chemical Name:2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneacetonitrile
CAS No.:261512-58-7
Molecular Formula:C₁₃H₁₀Cl₂N₄O₂
Molecular Weight:325.154
Hs Code.:

Synonyms:2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneacetonitrile

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Chemical Property of 2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneacetonitrile

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Technology Process of 2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneacetonitrile

There total 6 articles about 2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 261512-57-6
2-[3,5-dichloro-4-(1-cyano-1-methylethyl)phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carboxylic acid

: 261512-58-7
2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneacetonitrile

Guidance literature:: With mercaptoacetic acid; at 100 ℃; for 4h;
DOI:10.1021/jm049479m

Reference yield:

: 261512-47-4
2,6-dichloro-α,α-dimethyl-4-nitrobenzeneacetonitrile

: 261512-58-7
2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneacetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 15.0 g / H₂ / Raney Ni / methanol / 1 h / 20 °C / 2250.18 Torr

2.1: aq. HCl; AcOH; NaNO₂ / 1.83 h / 10 °C

2.2: 84 percent / aq. NaOAc / 0.67 h

3.1: KOAc; AcOH / 3 h / 120 °C

4.1: 100.6 g / aq. HCl / 4 h / Heating

5.1: 44 percent / thioglycolic acid / 4 h / 100 °C

With hydrogenchloride; hydrogen; potassium acetate; acetic acid; mercaptoacetic acid; sodium nitrite; nickel; In methanol;
DOI:10.1021/jm049479m

Reference yield:

: ethyl [[2-[3,5-dichloro-4-(1-cyano-1-methylethyl)phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazin-6-yl]carbonyl]carbamate

: 261512-58-7
2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneacetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 100.6 g / aq. HCl / 4 h / Heating

2: 44 percent / thioglycolic acid / 4 h / 100 °C

With hydrogenchloride; mercaptoacetic acid;
DOI:10.1021/jm049479m