2-(1,1''-BIPHENYL-4-YLOXY)-2-METHYLPROPANOIC ACID

Base Information

• Chemical Name: 2-(1,1''-BIPHENYL-4-YLOXY)-2-METHYLPROPANOIC ACID
• CAS No.: 1222-74-8
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.301
• Hs Code.: 2918990090
• Mol file: 1222-74-8.mol

Synonyms:Propionicacid, 2-(4-biphenylyloxy)-2-methyl- (6CI,7CI,8CI); NSC 523922

Chemical Property of 2-(1,1''-BIPHENYL-4-YLOXY)-2-METHYLPROPANOIC ACID

Chemical Property:

• Vapor Pressure: 1.08E-07mmHg at 25°C
• Boiling Point: 416.8°Cat760mmHg
• Flash Point: 153.9°C
• PSA: 46.53000
• Density: 1.149g/cm³
• LogP: 3.59560

Purity/Quality:

98%min ^*data from raw suppliers

2-(1,1'-Biphenyl-4-yloxy)-2-methylpropanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(1,1''-BIPHENYL-4-YLOXY)-2-METHYLPROPANOIC ACID

There total 2 articles about 2-(1,1''-BIPHENYL-4-YLOXY)-2-METHYLPROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

chloroform (67-66-3,8013-54-5) + 4-Phenylphenol (92-69-3) + acetone (67-64-1) → 2-(4-phenylphenoxy)-2-methylpropionic acid (1222-74-8)

Guidance literature:

With sodium hydroxide; Heating;

DOI:10.1021/jm00130a021

Reference yield:

→ 2-(4-phenylphenoxy)-2-methylpropionic acid (1222-74-8)

Guidance literature:

4-Phenyl-phenol (4-Hydroxy-biphenyl), Acn., Chlf., NaOH;

Reference yield:

4-(3-Aminopropyl)morpholine (123-00-2) + 2-(4-phenylphenoxy)-2-methylpropionic acid (1222-74-8) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → 2-(biphenyl-4-yloxy)-2-methyl-N-[1-(3-morpholin-4-yl-propylcarbamoyl)-2-phenyl-ethyl]-propionamide

Guidance literature:

Multistep reaction;

DOI:10.1016/j.bmcl.2004.11.045

upstream raw materials:

chloroform

4-Phenylphenol

acetone