(S)-methyl 3-(4,5-bis(benzyloxy)-2-nitrophenyl)-2-((tertbutoxycarbonyl)amino)propanoate

Base Information

Chemical Name:(S)-methyl 3-(4,5-bis(benzyloxy)-2-nitrophenyl)-2-((tertbutoxycarbonyl)amino)propanoate
CAS No.:1427521-83-2
Molecular Formula:C₂₉H₃₂N₂O₈
Molecular Weight:536.582
Hs Code.:

Synonyms:(S)-methyl 3-(4,5-bis(benzyloxy)-2-nitrophenyl)-2-((tertbutoxycarbonyl)amino)propanoate

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Chemical Property of (S)-methyl 3-(4,5-bis(benzyloxy)-2-nitrophenyl)-2-((tertbutoxycarbonyl)amino)propanoate

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Technology Process of (S)-methyl 3-(4,5-bis(benzyloxy)-2-nitrophenyl)-2-((tertbutoxycarbonyl)amino)propanoate

There total 4 articles about (S)-methyl 3-(4,5-bis(benzyloxy)-2-nitrophenyl)-2-((tertbutoxycarbonyl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 125228-11-7
3-(3,4-bis-benzyloxyphenyl)-2-tert-(butoxycarbonylamino)propionic acid methyl ester

: 1427521-83-2
(S)-methyl 3-(4,5-bis(benzyloxy)-2-nitrophenyl)-2-((tertbutoxycarbonyl)amino)propanoate

Guidance literature:: With nitric acid; acetic anhydride; acetic acid; at 15 ℃; for 4h;
DOI:10.1021/ol400490s

Reference yield:

: 7101-51-1
L-DOPA methyl ester

: 1427521-83-2
(S)-methyl 3-(4,5-bis(benzyloxy)-2-nitrophenyl)-2-((tertbutoxycarbonyl)amino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / methanol / 20.25 h / 0 - 20 °C

2.1: sodium iodide; potassium carbonate / acetone / 1 h / 20 °C

2.2: 22 h / Reflux

3.1: nitric acid; acetic acid; acetic anhydride / 4 h / 15 °C

With nitric acid; acetic anhydride; potassium carbonate; acetic acid; triethylamine; sodium iodide; In methanol; acetone;
DOI:10.1021/ol400490s

Reference yield:

: 37169-36-1
methyl (S)-2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)propanoate

: 1427521-83-2
(S)-methyl 3-(4,5-bis(benzyloxy)-2-nitrophenyl)-2-((tertbutoxycarbonyl)amino)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium iodide; potassium carbonate / acetone / 1 h / 20 °C

1.2: 22 h / Reflux

2.1: nitric acid; acetic acid; acetic anhydride / 4 h / 15 °C

With nitric acid; acetic anhydride; potassium carbonate; acetic acid; sodium iodide; In acetone;
DOI:10.1021/ol400490s