methyl-5-(5-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-[1,3,4]oxadiazol-2-yl)-pyridine

Base Information

Chemical Name:methyl-5-(5-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-[1,3,4]oxadiazol-2-yl)-pyridine
CAS No.:1609575-52-1
Molecular Formula:C₂₄H₂₄F₆N₄O
Molecular Weight:498.471
Hs Code.:

Synonyms:methyl-5-(5-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-[1,3,4]oxadiazol-2-yl)-pyridine

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Chemical Property of methyl-5-(5-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-[1,3,4]oxadiazol-2-yl)-pyridine

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Technology Process of methyl-5-(5-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-[1,3,4]oxadiazol-2-yl)-pyridine

There total 4 articles about methyl-5-(5-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-[1,3,4]oxadiazol-2-yl)-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 197079-25-7
6-methylpyridine-3-carbohydrazide

: 1602924-01-5
4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid

: 1609575-52-1
methyl-5-(5-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-[1,3,4]oxadiazol-2-yl)-pyridine

Guidance literature:: With trichlorophosphate; at 110 ℃; for 4h;

Reference yield:

: 328-62-1
4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester

: 1609575-52-1
methyl-5-(5-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-[1,3,4]oxadiazol-2-yl)-pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / tetrahydrofuran; water / 0.33 h / 0 °C

1.2: 0.5 h

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

3.1: sodium hydroxide; ethanol / 0.5 h / 90 °C

4.1: trichlorophosphate / 4 h / 110 °C

With ethanol; sodium tris(acetoxy)borohydride; acetic acid; potassium hydroxide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 4,4,4-trifluoro-3-formyl-butyric acid ethyl ester

: 1609575-52-1
methyl-5-(5-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-[1,3,4]oxadiazol-2-yl)-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

2: sodium hydroxide; ethanol / 0.5 h / 90 °C

3: trichlorophosphate / 4 h / 110 °C

With ethanol; sodium tris(acetoxy)borohydride; acetic acid; sodium hydroxide; trichlorophosphate; In dichloromethane;