methyl 2-acetylamino-6-(2,2-dimethylpropionylamino)-3-(2-hydroxymethylfuran-3-yl)benzoate

Base Information

Chemical Name:methyl 2-acetylamino-6-(2,2-dimethylpropionylamino)-3-(2-hydroxymethylfuran-3-yl)benzoate
CAS No.:1412976-01-2
Molecular Formula:C₂₀H₂₄N₂O₆
Molecular Weight:388.42
Hs Code.:

Synonyms:methyl 2-acetylamino-6-(2,2-dimethylpropionylamino)-3-(2-hydroxymethylfuran-3-yl)benzoate

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Chemical Property of methyl 2-acetylamino-6-(2,2-dimethylpropionylamino)-3-(2-hydroxymethylfuran-3-yl)benzoate

Chemical Property:

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Technology Process of methyl 2-acetylamino-6-(2,2-dimethylpropionylamino)-3-(2-hydroxymethylfuran-3-yl)benzoate

There total 6 articles about methyl 2-acetylamino-6-(2,2-dimethylpropionylamino)-3-(2-hydroxymethylfuran-3-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1412976-03-4
methyl 2-acetylamino-3-[2-(tert-butyldimethylsilanyloxymethyl)-furan-3-yl]-6-(2,2-dimethylpropionylamino)benzoate

: 1412976-01-2
methyl 2-acetylamino-6-(2,2-dimethylpropionylamino)-3-(2-hydroxymethylfuran-3-yl)benzoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.666667h;

Reference yield:

: 1356113-88-6
methyl 3-bromo-2,6-diaminobenzoate

: 1412976-01-2
methyl 2-acetylamino-6-(2,2-dimethylpropionylamino)-3-(2-hydroxymethylfuran-3-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1.25 h / 70 °C / Inert atmosphere

2: sodium hydrogencarbonate / ethyl acetate; water / 2.5 h / 0 - 20 °C

3: dichloromethane; pyridine / 1 h / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.67 h / 0 °C

With tetrabutyl ammonium fluoride; sodium hydrogencarbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; pyridine; dichloromethane; water; ethyl acetate;

Reference yield:

: 90050-54-7
methyl 6-amino-3-bromo-2-nitrobenzoate

: 1412976-01-2
methyl 2-acetylamino-6-(2,2-dimethylpropionylamino)-3-(2-hydroxymethylfuran-3-yl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol; iron / water; formic acid; acetic acid / 2 h / 20 °C

2: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1.25 h / 70 °C / Inert atmosphere

3: sodium hydrogencarbonate / ethyl acetate; water / 2.5 h / 0 - 20 °C

4: dichloromethane; pyridine / 1 h / 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.67 h / 0 °C

With ethanol; tetrabutyl ammonium fluoride; iron; sodium hydrogencarbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; pyridine; formic acid; dichloromethane; water; acetic acid; ethyl acetate;