methyl 2-acetylamino-3-[2-(tert-butyldimethylsilanyloxymethyl)-furan-3-yl]-6-(2,2-dimethylpropionylamino)benzoate

Base Information

Chemical Name:methyl 2-acetylamino-3-[2-(tert-butyldimethylsilanyloxymethyl)-furan-3-yl]-6-(2,2-dimethylpropionylamino)benzoate
CAS No.:1412976-03-4
Molecular Formula:C₂₆H₃₈N₂O₆Si
Molecular Weight:502.683
Hs Code.:

Synonyms:methyl 2-acetylamino-3-[2-(tert-butyldimethylsilanyloxymethyl)-furan-3-yl]-6-(2,2-dimethylpropionylamino)benzoate

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Chemical Property of methyl 2-acetylamino-3-[2-(tert-butyldimethylsilanyloxymethyl)-furan-3-yl]-6-(2,2-dimethylpropionylamino)benzoate

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Technology Process of methyl 2-acetylamino-3-[2-(tert-butyldimethylsilanyloxymethyl)-furan-3-yl]-6-(2,2-dimethylpropionylamino)benzoate

There total 8 articles about methyl 2-acetylamino-3-[2-(tert-butyldimethylsilanyloxymethyl)-furan-3-yl]-6-(2,2-dimethylpropionylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1412976-05-6
methyl 2-amino-3-[2-(tert-butyldimethylsilanyloxymethyl)furan-3-yl]-6-(2,2-dimethylpropionylamino)-benzoate

: 75-36-5
acetyl chloride

: 1412976-03-4
methyl 2-acetylamino-3-[2-(tert-butyldimethylsilanyloxymethyl)-furan-3-yl]-6-(2,2-dimethylpropionylamino)benzoate

Guidance literature:: In pyridine; dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1356113-88-6
methyl 3-bromo-2,6-diaminobenzoate

: 1412976-03-4
methyl 2-acetylamino-3-[2-(tert-butyldimethylsilanyloxymethyl)-furan-3-yl]-6-(2,2-dimethylpropionylamino)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1.25 h / 70 °C / Inert atmosphere

2: sodium hydrogencarbonate / ethyl acetate; water / 2.5 h / 0 - 20 °C

3: dichloromethane; pyridine / 1 h / 20 °C

With sodium hydrogencarbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; pyridine; dichloromethane; water; ethyl acetate;

Reference yield:

: 1412976-11-4
3-bromo-2-(tert-butyldimethylsilanyloxymethyl)furan

: 1412976-03-4
methyl 2-acetylamino-3-[2-(tert-butyldimethylsilanyloxymethyl)-furan-3-yl]-6-(2,2-dimethylpropionylamino)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; diethyl ether / 2.5 h / -70 °C

1.2: 1.75 h / 20 °C

2.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1.25 h / 70 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / ethyl acetate; water / 2.5 h / 0 - 20 °C

4.1: dichloromethane; pyridine / 1 h / 20 °C

With n-butyllithium; sodium hydrogencarbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; pyridine; diethyl ether; hexane; dichloromethane; water; ethyl acetate;