N⁶-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine

Base Information

• Chemical Name: N⁶-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine
• CAS No.: 131474-68-5
• Molecular Formula: C₃₀H₄₅N₅O₇Si₂
• Molecular Weight: 643.888

Synonyms:N⁶-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine

Chemical Property of N⁶-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine

Chemical Property:

Purity/Quality:

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Technology Process of N⁶-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine

There total 3 articles about N⁶-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) + N6-phenoxyacetyladenosine (119824-65-6) → N6-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine (131474-68-5)

Guidance literature:

With pyridine; at 20 ℃; for 18h;

DOI:10.1002/hlca.201000403

Reference yield:

Phenoxyacetyl chloride (701-99-5) → N6-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine (131474-68-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane

2.1: pyridine; chloro-trimethyl-silane / 2 h / 20 °C

2.2: 18.5 h / 4 - 20 °C

3.1: pyridine / 18 h / 20 °C

With pyridine; chloro-trimethyl-silane; In dichloromethane;

DOI:10.1002/hlca.201000403

Reference yield:

3-methyl-1-(phenoxyacetyl)-1H-imidazol-3-ium chloride → N6-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine (131474-68-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; chloro-trimethyl-silane / 2 h / 20 °C

1.2: 18.5 h / 4 - 20 °C

2.1: pyridine / 18 h / 20 °C

With pyridine; chloro-trimethyl-silane;

DOI:10.1002/hlca.201000403

upstream raw materials:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

N⁶-phenoxyacetyladenosine

Phenoxyacetyl chloride

Downstream raw materials:

N⁶-phenoxyacetyl-3’,5’-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2’-O-(methylthiomethyl)adenosine

N₆-(phenoxyacetyl)-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine

N₆-(phenoxyacetyl)-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)adenosine

N₆-(phenoxyacetyl)-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)adenosine 5'-[2-(2-nitrophenyl)propyl carbonate]

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