ethyl 3-(benzyl((2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl)amino)propanoate

Base Information

• Chemical Name: ethyl 3-(benzyl((2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl)amino)propanoate
• CAS No.: 1345962-36-8
• Molecular Formula: C₂₃H₃₀N₂O₄
• Molecular Weight: 398.502
• Mol file: 1345962-36-8.mol

Synonyms:ethyl 3-(benzyl((2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl)amino)propanoate

Chemical Property of ethyl 3-(benzyl((2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl)amino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(benzyl((2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl)amino)propanoate

There total 4 articles about ethyl 3-(benzyl((2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.6%

N-benzyl-1-(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanamine (1345962-35-7) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 3-(benzyl((2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl)amino)propanoate (1345962-36-8)

Guidance literature:

In ethanol; at 20 ℃;

Reference yield:

(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol (1136-52-3) → ethyl 3-(benzyl((2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl)amino)propanoate (1345962-36-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dipyridinium dichromate / dichloromethane

2.1: acetic acid / dichloromethane / 0.5 h

2.2: 4 h

3.1: ethanol / 20 °C

With dipyridinium dichromate; acetic acid; In ethanol; dichloromethane;

Reference yield:

5-hydroxy-6-methyl-3,4-pyridinedimethanol (65-23-6) → ethyl 3-(benzyl((2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl)amino)propanoate (1345962-36-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / 0.5 h / 20 °C

2.1: dipyridinium dichromate / dichloromethane

3.1: acetic acid / dichloromethane / 0.5 h

3.2: 4 h

4.1: ethanol / 20 °C

With dipyridinium dichromate; toluene-4-sulfonic acid; acetic acid; In ethanol; dichloromethane;

upstream raw materials:

N-benzyl-1-(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanamine

ethyl acrylate

5-hydroxy-6-methyl-3,4-pyridinedimethanol

(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

Downstream raw materials:

3-(benzyl((5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)methyl)amino)propanoic acid

3-(benzyl((4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl)amino)propanoic acid

5-((benzyl(2-carboxyethyl)amino)methyl)-3-hydroxy-2-methylisonicotinic acid