C₁₉H₁₉ClN₄O₂

Base Information

Chemical Name:C₁₉H₁₉ClN₄O₂
CAS No.:1192603-59-0
Molecular Formula:C₁₉H₁₉ClN₄O₂
Molecular Weight:370.838
Hs Code.:

C<sub>19</sub>H<sub>19</sub>ClN<sub>4</sub>O<sub>2</sub>

Synonyms:C₁₉H₁₉ClN₄O₂

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Chemical Property of C₁₉H₁₉ClN₄O₂

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Technology Process of C₁₉H₁₉ClN₄O₂

There total 6 articles about C₁₉H₁₉ClN₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1192603-06-7
5-[(2S,3R)-1-(3-chloro-4-cyanophenyl)-3-hydroxy-2-methylpyrrolidin-3-yl]pyridine-2-carboxylic acid

: 74-89-5
methylamine

: 1192603-59-0
C₁₉H₁₉ClN₄O₂

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmc.2012.11.001

Reference yield:

: 1192603-02-3
4-[(2S,3R)-3-(6-bromopyridin-3-yl)-3-hydroxy-2-methylpyrrolidin-1-yl]-2-chlorobenzonitrile

: 1192603-59-0
C₁₉H₁₉ClN₄O₂

Guidance literature:: Multi-step reaction with 3 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine; palladium diacetate / N,N-dimethyl-formamide / 16 h / 70 °C

2: sodium hydroxide; water / tetrahydrofuran; ethanol / 2 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran; N,N-dimethyl-formamide / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; water; palladium diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.001

Reference yield:

: 60702-69-4
2-chloro-4-fluorobenzonitrile

: 1192603-59-0
C₁₉H₁₉ClN₄O₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium bis(2-methoxyethoxy)aluminum dihydride / toluene; tetrahydrofuran / 3 h / 5 - 70 °C

1.2: 16 h / 20 °C

1.3: 1 h / 100 °C

2.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1 h / 20 °C

3.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine; palladium diacetate / N,N-dimethyl-formamide / 16 h / 70 °C

5.1: sodium hydroxide; water / tetrahydrofuran; ethanol / 2 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran; N,N-dimethyl-formamide / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; n-butyllithium; sodium bis(2-methoxyethoxy)aluminum dihydride; water; palladium diacetate; sulfur trioxide pyridine complex; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2012.11.001