N-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-fluoro-5-(4-morpholinyl)benzamide

Base Information

Chemical Name:N-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-fluoro-5-(4-morpholinyl)benzamide
CAS No.:1357621-32-9
Molecular Formula:C₂₃H₂₄FN₃O₃S
Molecular Weight:441.526
Hs Code.:

Synonyms:N-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-fluoro-5-(4-morpholinyl)benzamide

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Chemical Property of N-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-fluoro-5-(4-morpholinyl)benzamide

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Technology Process of N-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-fluoro-5-(4-morpholinyl)benzamide

There total 5 articles about N-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-fluoro-5-(4-morpholinyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1357620-87-1
4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-aminium chloride

: 295311-40-9
3-fluoro-5-(4-morpholinyl)benzoic acid

: 1357621-32-9
N-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-fluoro-5-(4-morpholinyl)benzamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2011.11.019

Reference yield:

: 147284-02-4
tert-butyl 4-(2-hydroxyethyl)-1,3-thiazol-2-ylcarbamate

: 1357621-32-9
N-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-fluoro-5-(4-morpholinyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; oil / 0.17 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With hydrogenchloride; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; oil;
DOI:10.1016/j.ejmech.2011.11.019

Reference yield:

: 1357620-80-4
tert-butyl 4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-ylcarbamate

: 1357621-32-9
N-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-fluoro-5-(4-morpholinyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.11.019