(3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-piperidin-1-yl]-methanone

Base Information

• Chemical Name: (3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-piperidin-1-yl]-methanone
• CAS No.: 184356-07-8
• Molecular Formula: C₂₆H₂₈NO₄P
• Molecular Weight: 449.486

Synonyms:(3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-piperidin-1-yl]-methanone

Chemical Property of (3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-piperidin-1-yl]-methanone

Chemical Property:

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Technology Process of (3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-piperidin-1-yl]-methanone

There total 3 articles about (3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-piperidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(diphenylphosphinoyl)piperidine (175857-65-5) + 3,4-dimethoxybenzoic acid chloride (3535-37-3) → (3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-piperidin-1-yl]-methanone (184356-07-8)

Guidance literature:

With triethylamine; In toluene; Heating;

DOI:10.1016/0040-4039(96)01765-0

Reference yield:

Tripiperidin (522-33-8,2583-71-3,60537-08-8) → (3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-piperidin-1-yl]-methanone (184356-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Heating

2: 76 percent / Et₃N / toluene

With triethylamine; In toluene; 1: Addition / 2: Acylation;

DOI:10.1002/(SICI)1099-0690(199909)1999:9<2345::AID-EJOC2345>3.0.CO;2-P

Reference yield:

Diphenylphosphine oxide (4559-70-0) → (3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-piperidin-1-yl]-methanone (184356-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Heating

2: 76 percent / Et₃N / toluene

With triethylamine; In toluene; 1: Addition / 2: Acylation;

DOI:10.1002/(SICI)1099-0690(199909)1999:9<2345::AID-EJOC2345>3.0.CO;2-P

upstream raw materials:

2-(diphenylphosphinoyl)piperidine

3,4-dimethoxybenzoic acid chloride

Tripiperidin

Diphenylphosphine oxide

Downstream raw materials:

{2-[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-piperidin-1-yl}-(3,4-dimethoxy-phenyl)-methanone

8,9-dimethoxy-4,6,11,11a-tetrahydro-1H-benzoquinolizine

(2-benzo[1,3]dioxol-5-ylmethyl-piperidin-1-yl)-(3,4-dimethoxy-phenyl)-methanone

(3,4-Dimethoxy-phenyl)-(2-methylene-piperidin-1-yl)-methanone

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