12-(4-hydroxy-3-methoxyphenyl)-9,9-dimethyl-9,10-dihydro-8H-benzo[a]xanthen-11(12H)-one

Base Information

• Chemical Name: 12-(4-hydroxy-3-methoxyphenyl)-9,9-dimethyl-9,10-dihydro-8H-benzo[a]xanthen-11(12H)-one
• CAS No.: 1011735-73-1
• Molecular Formula: C₂₆H₂₄O₄
• Molecular Weight: 400.474
• Mol file: 1011735-73-1.mol

Synonyms:12-(4-hydroxy-3-methoxyphenyl)-9,9-dimethyl-9,10-dihydro-8H-benzo[a]xanthen-11(12H)-one

Chemical Property of 12-(4-hydroxy-3-methoxyphenyl)-9,9-dimethyl-9,10-dihydro-8H-benzo[a]xanthen-11(12H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 12-(4-hydroxy-3-methoxyphenyl)-9,9-dimethyl-9,10-dihydro-8H-benzo[a]xanthen-11(12H)-one

There total 2 articles about 12-(4-hydroxy-3-methoxyphenyl)-9,9-dimethyl-9,10-dihydro-8H-benzo[a]xanthen-11(12H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dimedone (126-81-8) + vanillin (121-33-5,8014-42-4) + β-naphthol (135-19-3) → 12-(4-hydroxy-3-methoxyphenyl)-9,9-dimethyl-9,10-dihydro-8H-benzo[a]xanthen-11(12H)-one (1011735-73-1)

Guidance literature:

With sulfonated carbonized xylan-type hemicellulose; In neat (no solvent); at 90 ℃; for 2h; Green chemistry;

DOI:10.1039/c8nj01329b

Reference yield: 83.0%

β-naphthol (135-19-3) + 2,2'-(4-hydroxy-3-methoxyphenyl)methylene bis(3-hydroxy-5,5-dimethyl-2-cyclohexene-1-one) (71827-79-7) → 12-(4-hydroxy-3-methoxyphenyl)-9,9-dimethyl-9,10-dihydro-8H-benzo[a]xanthen-11(12H)-one (1011735-73-1) + 9-(4-hydroxy-3-methoxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione (30038-65-4)

Guidance literature:

With bismuth(lll) trifluoromethanesulfonate; In nitromethane; at 80 ℃; for 6h;

DOI:10.1002/adsc.201200299

Reference yield: 82.0%

12-(4-hydroxy-3-methoxyphenyl)-9,9-dimethyl-9,10-dihydro-8H-benzo[a]xanthen-11(12H)-one (1011735-73-1) → 9,9-dimethyl-12-(4-hydroxy-3-methoxyphenyl)-8,9,10,12-tetrahydrobenzo[a]xanthene-11-thione (1416451-23-4)

Guidance literature:

With Lawessons reagent; In toluene; for 0.833333h; Reflux;

DOI:10.1016/j.ejmech.2012.10.025

upstream raw materials:

dimedone

vanillin

β-naphthol

2,2'-(4-hydroxy-3-methoxyphenyl)methylene bis(3-hydroxy-5,5-dimethyl-2-cyclohexene-1-one)

Downstream raw materials:

9,9-dimethyl-12-(4-hydroxy-3-methoxyphenyl)-8,9,10,12-tetrahydrobenzo[a]xanthene-11-thione