6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid-(2-tert-butoxyethoxy)amide

Base Information

• Chemical Name: 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid-(2-tert-butoxyethoxy)amide
• CAS No.: 1604812-70-5
• Molecular Formula: C₂₁H₂₃BrF₂N₄O₃
• Molecular Weight: 497.339
• Mol file: 1604812-70-5.mol

Synonyms:6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid-(2-tert-butoxyethoxy)amide

Chemical Property of 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid-(2-tert-butoxyethoxy)amide

Chemical Property:

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid-(2-tert-butoxyethoxy)amide

There total 8 articles about 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid-(2-tert-butoxyethoxy)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-(2-(tert-butoxy)ethyl)hydroxylamine (1023742-13-3) + C18H12BrF2N5O (1604812-73-8) → 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid-(2-tert-butoxyethoxy)amide (1604812-70-5)

Guidance literature:

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 50 ℃; for 2h;

Reference yield:

N-(2-tert-butoxyethoxy)-6-[(4-bromo-2-fluorophenyl)amino]-7-fluoro-3H-benzimidazole-5-carboxamide + methyl iodide (74-88-4) → 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid-(2-tert-butoxyethoxy)amide (1604812-70-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at -10 - 65 ℃; for 2h; Solvent; Reagent/catalyst; Temperature; Green chemistry;

Reference yield:

methyl 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate (1415559-93-1) → 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid-(2-tert-butoxyethoxy)amide (1604812-70-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium trimethylsilonate / N,N-dimethyl-formamide; tetrahydrofuran / 1.67 h / 20 - 25 °C / Inert atmosphere

2: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 - 50 °C

3: N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 50 °C / Inert atmosphere

With potassium trimethylsilonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

O-(2-(tert-butoxy)ethyl)hydroxylamine

C₁₈H₁₂BrF₂N₅O

methyl 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate

methyl 5-amino-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate

Downstream raw materials:

6-(4-bromo-2-fluoro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide