(9H-fluoren-9-yl)methyl 4-(2-Azidophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:(9H-fluoren-9-yl)methyl 4-(2-Azidophenyl)-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.:1579291-48-7
Molecular Formula:C₂₆H₂₂N₄O₂
Molecular Weight:422.486
Hs Code.:

Synonyms:(9H-fluoren-9-yl)methyl 4-(2-Azidophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

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Chemical Property of (9H-fluoren-9-yl)methyl 4-(2-Azidophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

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Technology Process of (9H-fluoren-9-yl)methyl 4-(2-Azidophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

There total 5 articles about (9H-fluoren-9-yl)methyl 4-(2-Azidophenyl)-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1579291-74-9
2-(2-azidophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1579291-73-8
C₂₁H₁₈F₃NO₅S

: 1579291-48-7
(9H-fluoren-9-yl)methyl 4-(2-Azidophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; In tetrahydrofuran; water; at 80 ℃; for 1.5h; Reagent/catalyst; Time; Inert atmosphere;
DOI:10.1021/jo500252e

Reference yield:

: 191171-55-8
2-anilineboronic acid pinacol ester

: 1579291-48-7
(9H-fluoren-9-yl)methyl 4-(2-Azidophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 2-Methyl-2-nitropropane; trimethylsilylazide / acetonitrile / 1.5 h / 0 - 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate / water; tetrahydrofuran / 1.5 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; 2-Methyl-2-nitropropane; trimethylsilylazide; sodium hydrogencarbonate; In tetrahydrofuran; water; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1021/jo500252e

Reference yield:

: 615-36-1
2-bromoaniline

: 1579291-48-7
(9H-fluoren-9-yl)methyl 4-(2-Azidophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 120 °C / Inert atmosphere

2: 2-Methyl-2-nitropropane; trimethylsilylazide / acetonitrile / 1.5 h / 0 - 20 °C / Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate / water; tetrahydrofuran / 1.5 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 2-Methyl-2-nitropropane; trimethylsilylazide; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; 3: |Suzuki Coupling;
DOI:10.1021/jo500252e