N,N-dimethyl-3-(4-fluorophenylsulfonamino)-2-methoxy-5-(4-morpholinoquinazolin-6-yl)benzamide

Base Information

Chemical Name:N,N-dimethyl-3-(4-fluorophenylsulfonamino)-2-methoxy-5-(4-morpholinoquinazolin-6-yl)benzamide
CAS No.:1579281-62-1
Molecular Formula:C₂₈H₂₈FN₅O₅S
Molecular Weight:565.625
Hs Code.:

Synonyms:N,N-dimethyl-3-(4-fluorophenylsulfonamino)-2-methoxy-5-(4-morpholinoquinazolin-6-yl)benzamide

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Chemical Property of N,N-dimethyl-3-(4-fluorophenylsulfonamino)-2-methoxy-5-(4-morpholinoquinazolin-6-yl)benzamide

Chemical Property:

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Technology Process of N,N-dimethyl-3-(4-fluorophenylsulfonamino)-2-methoxy-5-(4-morpholinoquinazolin-6-yl)benzamide

There total 8 articles about N,N-dimethyl-3-(4-fluorophenylsulfonamino)-2-methoxy-5-(4-morpholinoquinazolin-6-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1579281-60-9
N,N-dimethyl-5-bromo-2-methoxy-3-(4-fluorophenylsulfonamino)benzamide

: 1404227-87-7
C₁₈H₂₄BN₃O₃

: 1579281-62-1
N,N-dimethyl-3-(4-fluorophenylsulfonamino)-2-methoxy-5-(4-morpholinoquinazolin-6-yl)benzamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In water; for 2h; Reflux; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.01.053

Reference yield:

: 1579281-56-3
N,N-dimethyl-5-bromo-2-methoxy-3-nitrobenzamide

: 1579281-62-1
N,N-dimethyl-3-(4-fluorophenylsulfonamino)-2-methoxy-5-(4-morpholinoquinazolin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; tin(II) chloride dihdyrate / water / 20 °C

2: pyridine / 0 - 20 °C

3: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 2 h / Reflux; Inert atmosphere

With pyridine; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tin(II) chloride dihdyrate; sodium carbonate; In water; 3: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.01.053

Reference yield:

: 307538-52-9
4-(6-bromoquinazolin-4-yl)morpholine

: 1579281-62-1
N,N-dimethyl-3-(4-fluorophenylsulfonamino)-2-methoxy-5-(4-morpholinoquinazolin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 2 h / Reflux; Inert atmosphere

2: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 2 h / Reflux; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium carbonate; In 1,2-dimethoxyethane; water; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.01.053