diethyl 1-(3-o-tolyl-7-(trimethylsilyl)isoquinolin-4-yl)hydrazine-1,2-dicarboxylate

Base Information

Chemical Name:diethyl 1-(3-o-tolyl-7-(trimethylsilyl)isoquinolin-4-yl)hydrazine-1,2-dicarboxylate
CAS No.:1352803-22-5
Molecular Formula:C₂₅H₃₁N₃O₄Si
Molecular Weight:465.624
Hs Code.:

Synonyms:diethyl 1-(3-o-tolyl-7-(trimethylsilyl)isoquinolin-4-yl)hydrazine-1,2-dicarboxylate

Suppliers and Price of diethyl 1-(3-o-tolyl-7-(trimethylsilyl)isoquinolin-4-yl)hydrazine-1,2-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diethyl 1-(3-o-tolyl-7-(trimethylsilyl)isoquinolin-4-yl)hydrazine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diethyl 1-(3-o-tolyl-7-(trimethylsilyl)isoquinolin-4-yl)hydrazine-1,2-dicarboxylate

There total 8 articles about diethyl 1-(3-o-tolyl-7-(trimethylsilyl)isoquinolin-4-yl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1417212-92-0
C₂₃H₃₁LiN₂Si

: 1972-28-7,218603-74-8
diethylazodicarboxylate

: 1352803-22-5
diethyl 1-(3-o-tolyl-7-(trimethylsilyl)isoquinolin-4-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; for 0.5h;

Reference yield: 55.0%

: 529-19-1
2-Methylbenzonitrile

: 1352802-98-2
2-methyl-5-(trimethylsilyl)benzaldehyde tert-butylimine

: 1972-28-7,218603-74-8
diethylazodicarboxylate

: 1352803-22-5
diethyl 1-(3-o-tolyl-7-(trimethylsilyl)isoquinolin-4-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: 2-methyl-5-(trimethylsilyl)benzaldehyde tert-butylimine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 1.16667h; Inert atmosphere;

2-Methylbenzonitrile; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

diethylazodicarboxylate; Further stages;
DOI:10.1002/anie.201104769

Reference yield:

: 1352802-80-2
2-methyl-5-(trimethylsilyl)benzaldehyde

: 1352803-22-5
diethyl 1-(3-o-tolyl-7-(trimethylsilyl)isoquinolin-4-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzene / 16 h / 80 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 1.17 h / 0 °C / Inert atmosphere

2.2: 0.25 h / -78 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; benzene;
DOI:10.1002/anie.201104769