7-benzoyl-5-chloro-2,3-dihydrobenzofuran-3-carboxylic acid

Base Information

Chemical Name:7-benzoyl-5-chloro-2,3-dihydrobenzofuran-3-carboxylic acid
CAS No.:1403663-26-2
Molecular Formula:C₁₆H₁₁ClO₄
Molecular Weight:302.714
Hs Code.:

Synonyms:7-benzoyl-5-chloro-2,3-dihydrobenzofuran-3-carboxylic acid

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Chemical Property of 7-benzoyl-5-chloro-2,3-dihydrobenzofuran-3-carboxylic acid

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Technology Process of 7-benzoyl-5-chloro-2,3-dihydrobenzofuran-3-carboxylic acid

There total 7 articles about 7-benzoyl-5-chloro-2,3-dihydrobenzofuran-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1403663-25-1
ethyl 7-benzoyl-5-chloro-2,3-dihydrobenzofuran-3-carboxylate

: 1403663-26-2
7-benzoyl-5-chloro-2,3-dihydrobenzofuran-3-carboxylic acid

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 24h;
DOI:10.1002/chem.201200683

Reference yield:

: 899795-65-4
5-chloro-3-benzofurancarboxylic acid ethyl ester

: 1403663-26-2
7-benzoyl-5-chloro-2,3-dihydrobenzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium / Inert atmosphere

2.1: sulfuric acid / 24 h / 30 °C / Inert atmosphere

3.1: Candida antarctica lipase B immobilized on acrylic resin (Novozyme 435) / 6 h / 0 °C / pH 8.5 / aq. phosphate buffer; Resolution of racemate; Inert atmosphere; Enzymatic reaction

4.1: aluminum (III) chloride / carbon disulfide / 72 h / 0 - 20 °C / Inert atmosphere

4.2: 168 h

5.1: hydrogenchloride / tetrahydrofuran; water / 24 h / 20 °C

With hydrogenchloride; aluminum (III) chloride; sulfuric acid; magnesium; In tetrahydrofuran; carbon disulfide; water; 4.1: Friedel Crafts acylation;
DOI:10.1002/chem.201200683

Reference yield:

: 5-chloro-2-hydroxy-2,3-dihydro-benzofuran-3-carboxylic acid ethyl ester

: 1403663-26-2
7-benzoyl-5-chloro-2,3-dihydrobenzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 0.25 h / 20 °C

2.1: magnesium / Inert atmosphere

3.1: sulfuric acid / 24 h / 30 °C / Inert atmosphere

4.1: Candida antarctica lipase B immobilized on acrylic resin (Novozyme 435) / 6 h / 0 °C / pH 8.5 / aq. phosphate buffer; Resolution of racemate; Inert atmosphere; Enzymatic reaction

5.1: aluminum (III) chloride / carbon disulfide / 72 h / 0 - 20 °C / Inert atmosphere

5.2: 168 h

6.1: hydrogenchloride / tetrahydrofuran; water / 24 h / 20 °C

With hydrogenchloride; aluminum (III) chloride; sulfuric acid; magnesium; In tetrahydrofuran; carbon disulfide; water; 5.1: Friedel Crafts acylation;
DOI:10.1002/chem.201200683