Ethyl 5-chlorobenzofuran-3-carboxylate

Base Information

• Chemical Name: Ethyl 5-chlorobenzofuran-3-carboxylate
• CAS No.: 899795-65-4
• Molecular Formula: C₁₁H₉ClO₃
• Molecular Weight: 224.644
• Mol file: 899795-65-4.mol

Synonyms:Ethyl 5-chlorobenzofuran-3-carboxylate;5-Chloro-3-ethoxycarbonylbenzofuran;5-Chloro-benzofuran-3-carboxylic acid ethyl ester;5-Chloro-3-benzofurancarboxylic acid ethyl ester

Chemical Property of Ethyl 5-chlorobenzofuran-3-carboxylate

Chemical Property:

• Melting Point: 58-63℃
• PSA: 39.44000
• LogP: 3.26290
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 5-chlorobenzofuran-3-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-38

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 5-chlorobenzofuran-3-carboxylate

There total 8 articles about Ethyl 5-chlorobenzofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

diazoacetic acid ethyl ester (623-73-4) + 5-chlorosalicyclaldehyde (635-93-8) → 5-chloro-3-benzofurancarboxylic acid ethyl ester (899795-65-4)

Guidance literature:

diazoacetic acid ethyl ester; 5-chlorosalicyclaldehyde; With tetrafluoroboric acid diethyl ether; In dichloromethane; at 20 - 36 ℃; for 12h; Inert atmosphere; Schlenk technique;

With sulfuric acid; for 0.5h; Inert atmosphere; Schlenk technique;

DOI:10.1002/cbdv.201800334

Reference yield: 64.0%

ethyl (E)-3-(4-chlorophenoxy)acrylate (28991-20-0) → 5-chloro-3-benzofurancarboxylic acid ethyl ester (899795-65-4)

Guidance literature:

With palladium diacetate; silver trifluoroacetate; triphenylphosphine; In benzene; at 110 ℃; for 24h;

DOI:10.1021/jo200317f

Reference yield:

5-chloro-2-hydroxy-2,3-dihydro-benzofuran-3-carboxylic acid ethyl ester → 5-chloro-3-benzofurancarboxylic acid ethyl ester (899795-65-4)

Guidance literature:

With sulfuric acid; In dichloromethane;

DOI:10.1055/s-2006-926454

upstream raw materials:

5-chlorosalicyclaldehyde

ethyl (E)-3-(4-chlorophenoxy)acrylate

4-chloro-phenol

propynoic acid ethyl ester

Downstream raw materials:

5-chloro-7-(4-chlorobenzoyl)-2,3-dihydro-1-benzofuran-3-carboxylic acid

7-benzoyl-5-chloro-2,3-dihydrobenzofuran-3-carboxylic acid

methyl 7-benzoyl-5-chloro-2,3-dihydro-1-benzofuran-3-carboxylate

7-benzoyl-5-chloro-2,3-dihydrobenzofuran-3-carboxylic acid

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