4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl dihydrogen phosphate

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Chemical Name:4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl dihydrogen phosphate
CAS No.:1224949-22-7
Molecular Formula:C₂₃H₂₇N₂O₆P
Molecular Weight:458.451
Hs Code.:

Synonyms:4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl dihydrogen phosphate

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Chemical Property of 4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl dihydrogen phosphate

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Technology Process of 4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl dihydrogen phosphate

There total 9 articles about 4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1224950-18-8
dibenzyl 4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl phosphate

: 1224949-22-7
4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl dihydrogen phosphate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; at 20 ℃; for 2.5h;

Reference yield:

: 1224949-36-3
3-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)-1-(p-tolyl)-2-propyn-1-one

: 1224949-22-7
4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / ethanol / 0.5 h / 20 °C

1.2: 15 h / 20 °C

2.1: hydrogenchloride; water / tetrahydrofuran / 15 h / 20 °C

2.2: 0 °C

3.1: sodium tetrahydroborate; methanol / 2 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 15 h / 20 °C / Cooling with ice

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 2.5 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; water; hydrogen; sodium hydride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; ethyl acetate; mineral oil;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1224949-22-7
4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -76 °C

1.2: 2 h / -74 °C

2.1: potassium carbonate; methanol / 2 h / 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.92 h / -72 °C

3.2: 0.58 h / -72 °C

4.1: manganese(IV) oxide / dichloromethane / 15 h / 20 °C

5.1: triethylamine / ethanol / 0.5 h / 20 °C

5.2: 15 h / 20 °C

6.1: hydrogenchloride; water / tetrahydrofuran / 15 h / 20 °C

6.2: 0 °C

7.1: sodium tetrahydroborate; methanol / 2 h / 20 °C

8.1: sodium hydride / tetrahydrofuran; mineral oil / 15 h / 20 °C / Cooling with ice

9.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 2.5 h / 20 °C

With hydrogenchloride; methanol; manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; water; hydrogen; sodium hydride; potassium carbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; ethyl acetate; mineral oil;