4-chloro-1-methyl-5-methanesulfonyl-3-[3-amino-4-(trifluoromethyl)phenoxy]pyrazole

Base Information

Chemical Name:4-chloro-1-methyl-5-methanesulfonyl-3-[3-amino-4-(trifluoromethyl)phenoxy]pyrazole
CAS No.:182289-32-3
Molecular Formula:C₁₂H₁₁ClF₃N₃O₃S
Molecular Weight:369.752
Hs Code.:

Synonyms:4-chloro-1-methyl-5-methanesulfonyl-3-[3-amino-4-(trifluoromethyl)phenoxy]pyrazole

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Chemical Property of 4-chloro-1-methyl-5-methanesulfonyl-3-[3-amino-4-(trifluoromethyl)phenoxy]pyrazole

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Technology Process of 4-chloro-1-methyl-5-methanesulfonyl-3-[3-amino-4-(trifluoromethyl)phenoxy]pyrazole

There total 5 articles about 4-chloro-1-methyl-5-methanesulfonyl-3-[3-amino-4-(trifluoromethyl)phenoxy]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 182289-69-6
4-chloro-1-methyl-5-methanesulfonyl-3-[3-nitro-4-(trifluoromethyl)phenoxy]pyrazole

: 182289-32-3
4-chloro-1-methyl-5-methanesulfonyl-3-[3-amino-4-(trifluoromethyl)phenoxy]pyrazole

Guidance literature:: With iron; acetic acid; at 80 ℃; for 0.5h;
DOI:10.1021/jf9601978

Reference yield:

: 367-86-2
1-fluoro-2-nitro-4-trifluoromethyl-benzene

: 182289-32-3
4-chloro-1-methyl-5-methanesulfonyl-3-[3-amino-4-(trifluoromethyl)phenoxy]pyrazole

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 10percent Pd/C / ethanol / 15 h / 2585.7 Torr

2: 3 h / Heating

3: 1.) conc. H₂SO₄, HNO₃, 2.) 12 N aq. HCl, 3.) t-BuONO

4: 65 percent / K₂CO₃ / dimethylsulfoxide / 24 h / 80 °C

5: 91 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 1.) 0 deg C, 20 min, 2.) RT, 10 h

6: 100 percent / aq. AcOH, Fe / 0.5 h / 80 °C

With hydrogenchloride; tert.-butylnitrite; sulfuric acid; hydrogen; nitric acid; iron; potassium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jf9601978

Reference yield:

: 535-52-4
2-fluoro-5-(trifluoromethyl)aniline

: 182289-32-3
4-chloro-1-methyl-5-methanesulfonyl-3-[3-amino-4-(trifluoromethyl)phenoxy]pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1: 3 h / Heating

2: 1.) conc. H₂SO₄, HNO₃, 2.) 12 N aq. HCl, 3.) t-BuONO

3: 65 percent / K₂CO₃ / dimethylsulfoxide / 24 h / 80 °C

4: 91 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 1.) 0 deg C, 20 min, 2.) RT, 10 h

5: 100 percent / aq. AcOH, Fe / 0.5 h / 80 °C

With hydrogenchloride; tert.-butylnitrite; sulfuric acid; nitric acid; iron; potassium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jf9601978