4-chloro-1-methyl-5-methanesulfonyl-3-[3-acetamido-4-(trifluoromethyl)phenoxy]pyrazole

Base Information

Chemical Name:4-chloro-1-methyl-5-methanesulfonyl-3-[3-acetamido-4-(trifluoromethyl)phenoxy]pyrazole
CAS No.:182288-71-7
Molecular Formula:C₁₄H₁₃ClF₃N₃O₄S
Molecular Weight:411.789
Hs Code.:

Synonyms:4-chloro-1-methyl-5-methanesulfonyl-3-[3-acetamido-4-(trifluoromethyl)phenoxy]pyrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-chloro-1-methyl-5-methanesulfonyl-3-[3-acetamido-4-(trifluoromethyl)phenoxy]pyrazole

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Technology Process of 4-chloro-1-methyl-5-methanesulfonyl-3-[3-acetamido-4-(trifluoromethyl)phenoxy]pyrazole

There total 5 articles about 4-chloro-1-methyl-5-methanesulfonyl-3-[3-acetamido-4-(trifluoromethyl)phenoxy]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 108-24-7
acetic anhydride

: 182289-32-3
4-chloro-1-methyl-5-methanesulfonyl-3-[3-amino-4-(trifluoromethyl)phenoxy]pyrazole

: 182288-71-7
4-chloro-1-methyl-5-methanesulfonyl-3-[3-acetamido-4-(trifluoromethyl)phenoxy]pyrazole

Guidance literature:: at 50 ℃; for 3h;
DOI:10.1021/jf9601978

Reference yield:

: 535-52-4
2-fluoro-5-(trifluoromethyl)aniline

: 182288-71-7
4-chloro-1-methyl-5-methanesulfonyl-3-[3-acetamido-4-(trifluoromethyl)phenoxy]pyrazole

Guidance literature:: Multi-step reaction with 6 steps

1: 3 h / Heating

2: 1.) conc. H₂SO₄, HNO₃, 2.) 12 N aq. HCl, 3.) t-BuONO

3: 65 percent / K₂CO₃ / dimethylsulfoxide / 24 h / 80 °C

4: 91 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 1.) 0 deg C, 20 min, 2.) RT, 10 h

5: 100 percent / aq. AcOH, Fe / 0.5 h / 80 °C

6: 93 percent / 3 h / 50 °C

With hydrogenchloride; tert.-butylnitrite; sulfuric acid; nitric acid; iron; potassium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jf9601978

Reference yield:

: 349-27-9
N-(2-fluoro-5-(trifluoromethyl)phenyl)acetamide

: 182288-71-7
4-chloro-1-methyl-5-methanesulfonyl-3-[3-acetamido-4-(trifluoromethyl)phenoxy]pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) conc. H₂SO₄, HNO₃, 2.) 12 N aq. HCl, 3.) t-BuONO

2: 65 percent / K₂CO₃ / dimethylsulfoxide / 24 h / 80 °C

3: 91 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 1.) 0 deg C, 20 min, 2.) RT, 10 h

4: 100 percent / aq. AcOH, Fe / 0.5 h / 80 °C

5: 93 percent / 3 h / 50 °C

With hydrogenchloride; tert.-butylnitrite; sulfuric acid; nitric acid; iron; potassium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jf9601978