[¹⁸F]-4-bromo-4′-fluorobenzophenone

Base Information

• Chemical Name: [¹⁸F]-4-bromo-4′-fluorobenzophenone
• CAS No.: 1453864-88-4
• Molecular Formula: C₁₃H₈BrFO
• Molecular Weight: 278.11
• Mol file: 1453864-88-4.mol

Synonyms:[¹⁸F]-4-bromo-4′-fluorobenzophenone

Chemical Property of [¹⁸F]-4-bromo-4′-fluorobenzophenone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of [¹⁸F]-4-bromo-4′-fluorobenzophenone

There total 3 articles about [¹⁸F]-4-bromo-4′-fluorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

[4-(4”-bromophenylcarbonyl)phenyl](4’-methoxyphenyl)tosylate (1448602-20-7) → [18F]-4-bromo-4′-fluorobenzophenone (1453864-88-4) + [18F]1-fluoro-4-methoxybenzene

Guidance literature:

With K[18F]F-4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane complex; In N,N-dimethyl-formamide; at 200 ℃; for 0.0522222h;

DOI:10.1039/c3ob41353e

Reference yield:

4-bromo-4'-iodobenzophenone (609820-28-2) → [18F]-4-bromo-4′-fluorobenzophenone (1453864-88-4)

Guidance literature:

4-bromo-4'-iodobenzophenone; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 24h;

With [2.2.2]cryptande; tetrabutylammonium bicarbonate; [18F]fluoride ion, cyclotron produced, NCA; In N,N-dimethyl acetamide; water; at 120 ℃; for 0.166667h;

DOI:10.1021/acs.orglett.8b03450

Reference yield:

[4-(4”-bromophenylcarbonyl)phenyl](4’-methoxyphenyl)tosylate (1448602-20-7) → [18F]-4-bromo-4′-fluorobenzophenone (1453864-88-4)

Guidance literature:

With 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; potassium carbonate; In water; N,N-dimethyl-formamide; at 150 ℃; for 0.0502778h; Temperature;

DOI:10.1039/c3ob40742j

upstream raw materials:

[4-(4”-bromophenylcarbonyl)phenyl](4’-methoxyphenyl)tosylate

4-bromo-4'-iodobenzophenone