N-(5-{[(2-chlorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-yl)-2-(phenylcarbonyl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide

Base Information

Chemical Name:N-(5-{[(2-chlorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-yl)-2-(phenylcarbonyl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide
CAS No.:1052693-65-8
Molecular Formula:C₂₆H₂₁ClN₄O₃S
Molecular Weight:504.997
Hs Code.:

Synonyms:N-(5-{[(2-chlorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-yl)-2-(phenylcarbonyl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide

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Chemical Property of N-(5-{[(2-chlorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-yl)-2-(phenylcarbonyl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide

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Technology Process of N-(5-{[(2-chlorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-yl)-2-(phenylcarbonyl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide

There total 4 articles about N-(5-{[(2-chlorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-yl)-2-(phenylcarbonyl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1052692-95-1
N-(5-{[(2-chlorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

: 98-88-4
benzoyl chloride

: 1052693-65-8
N-(5-{[(2-chlorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-yl)-2-(phenylcarbonyl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 84138-74-9
5-[(2-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-amine

: 1052693-65-8
N-(5-{[(2-chlorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-yl)-2-(phenylcarbonyl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

3.1: pyridine / tetrahydrofuran / 20 °C

With pyridine; hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 119869-02-2
2-{[(2-chlorophenyl)oxy]acetyl}hydrazinecarbothioamide

: 1052693-65-8
N-(5-{[(2-chlorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-yl)-2-(phenylcarbonyl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanesulfonyl chloride / toluene / 2 h / Heating / reflux

1.2: pH 9

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 20 °C

3.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

4.1: pyridine / tetrahydrofuran / 20 °C

With pyridine; hydrogenchloride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene;