1,3,4-Thiadiazol-2-amine, 5-[(2-chlorophenoxy)methyl]-

Base Information

• Chemical Name: 1,3,4-Thiadiazol-2-amine, 5-[(2-chlorophenoxy)methyl]-
• CAS No.: 84138-74-9
• Molecular Formula: C9H8ClN3OS
• Molecular Weight: 241.701

Synonyms:5-(2-Chloro-phenoxymethyl)-[1,3,4]thiadiazol-2-ylamine;5-{[(2-chlorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-amine;2-Amino-5-(2-chlorophenoxymethyl)-1,3,4-thiadiazole;5-(2-chlorophenoxymethyl)-2-amino-1,3,4-thiadiazole;

Chemical Property of 1,3,4-Thiadiazol-2-amine, 5-[(2-chlorophenoxy)methyl]-

Chemical Property:

• Melting Point: 120 - 122 °C
• PSA: 89.27000
• LogP: 2.93390

Purity/Quality:

5-((2-Chlorophenoxy)methyl)-1,3,4-thiadiazol-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,4-Thiadiazol-2-amine, 5-[(2-chlorophenoxy)methyl]-

There total 6 articles about 1,3,4-Thiadiazol-2-amine, 5-[(2-chlorophenoxy)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(2-chlorophenoxy)acetic acid (614-61-9) + thiosemicarbazide (79-19-6) → 5-[(2-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-amine (84138-74-9)

Guidance literature:

With poly(ethylene glycol) supported dichlorophosphate; at 120 ℃; for 0.166667h; microwave irradiation;

Reference yield: 60.0%

2-{[(2-chlorophenyl)oxy]acetyl}hydrazinecarbothioamide (119869-02-2) → 5-[(2-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-amine (84138-74-9)

Guidance literature:

2-{[(2-chlorophenyl)oxy]acetyl}hydrazinecarbothioamide; With methanesulfonic acid; In toluene; for 2h; Heating / reflux;

With ammonia; In water; pH=9;

Reference yield:

2-monochlorophenol (95-57-8) → 5-[(2-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-amine (84138-74-9)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 8 h / Reflux

2: hydrazine hydrate / methanol / 1 h / 20 °C

3: ethanol / 4 h / Reflux

4: phosphoric acid / 2 h / 120 °C

With ethanol; phosphoric acid; potassium carbonate; hydrazine hydrate; In methanol; acetone;

DOI:10.1016/j.bmc.2010.11.034

upstream raw materials:

2-{[(2-chlorophenyl)oxy]acetyl}hydrazinecarbothioamide

(2-chlorophenoxy)acetic acid

thiosemicarbazide

(2-chlorophenoxy)acetic acid hydrazide

Downstream raw materials:

[5-(2-Chloro-phenoxymethyl)-[1,3,4]thiadiazol-2-yl]-[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-amine

2-(Chloroacetamido)-5-(2-chlorophenoxymethyl)-1,3,4-thiadiazole

C₁₀H₈ClN₃O₂S

C₁₃H₁₀ClN₃O₂S

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 84138-74-9 1,3,4-Thiadiazol-2-amine, 5-[(2-chlorophenoxy)methyl]-

Send

Send

Metric Ton KG G Pound L ML

Send

Send