4-chloro-6-(4-methoxybenzyloxy)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

Base Information

Chemical Name:4-chloro-6-(4-methoxybenzyloxy)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine
CAS No.:1251166-18-3
Molecular Formula:C₁₆H₁₁ClF₃N₃O₂S
Molecular Weight:401.796
Hs Code.:

Synonyms:4-chloro-6-(4-methoxybenzyloxy)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

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Chemical Property of 4-chloro-6-(4-methoxybenzyloxy)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

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Technology Process of 4-chloro-6-(4-methoxybenzyloxy)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

There total 5 articles about 4-chloro-6-(4-methoxybenzyloxy)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1251166-17-2
4,6-dichloro-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

: 105-13-5
4-Methoxybenzyl alcohol

: 1251166-18-3
4-chloro-6-(4-methoxybenzyloxy)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

Guidance literature:: With NaH; sodium hydrogencarbonate; In pentane;

Reference yield:

: 79247-86-2
4-trifluoromethylthiazole-2-carboxylic acid ethyl ester

: 1251166-18-3
4-chloro-6-(4-methoxybenzyloxy)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium chloride; trimethylaluminum / toluene / 17 h / 0 - 80 °C

2.1: sodium ethanolate / ethanol / 24.5 h / 20 °C / Reflux

2.2: pH 5

3.1: N,N-diethylaniline; trichlorophosphate / 1 h / 0 - 100 °C

4.1: sodium hydride / mineral oil / 1 h / 0 °C

With trimethylaluminum; sodium ethanolate; sodium hydride; ammonium chloride; N,N-diethylaniline; trichlorophosphate; In ethanol; toluene; mineral oil;

Reference yield:

: 4-(trifluoromethyl)-1,3-thiazole-2-carboxylic acid

: 1251166-18-3
4-chloro-6-(4-methoxybenzyloxy)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / ethanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

2: ammonium chloride / AlMe₃ / toluene; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; methanol

3: NaOEt / ethanol; water

4: N,N-diethylaniline / trichlorophosphate; pentane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

5: sodium hydrogencarbonate; NaH / pentane

With thionyl chloride; NaH; NaOEt; ammonium chloride; sodium hydrogencarbonate; N,N-diethylaniline; AlMe₃; In methanol; ethanol; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; toluene; trichlorophosphate; pentane;