4-(4-methoxybenzyloxy)-6-(5-methylthiophen-2-yl)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

Base Information

Chemical Name:4-(4-methoxybenzyloxy)-6-(5-methylthiophen-2-yl)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine
CAS No.:1251166-34-3
Molecular Formula:C₂₁H₁₆F₃N₃O₂S₂
Molecular Weight:463.504
Hs Code.:

Synonyms:4-(4-methoxybenzyloxy)-6-(5-methylthiophen-2-yl)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

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Chemical Property of 4-(4-methoxybenzyloxy)-6-(5-methylthiophen-2-yl)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

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Technology Process of 4-(4-methoxybenzyloxy)-6-(5-methylthiophen-2-yl)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

There total 6 articles about 4-(4-methoxybenzyloxy)-6-(5-methylthiophen-2-yl)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1251166-18-3
4-chloro-6-(4-methoxybenzyloxy)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

: 162607-20-7
(5-methylthiophen-2-yl)boronic acid

: 1251166-34-3
4-(4-methoxybenzyloxy)-6-(5-methylthiophen-2-yl)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

Guidance literature:: With sodium carbonate; palladium diacetate; triphenylphosphine; In 1,4-dioxane; water; at 120 ℃; for 0.5h; Irradiation;

Reference yield:

: 1251166-16-1
2-(4-trifluoromethylthiazol-2-yl)pyrimidin-4,6-diol

: 1251166-34-3
4-(4-methoxybenzyloxy)-6-(5-methylthiophen-2-yl)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diethylaniline; trichlorophosphate / 1 h / 0 - 100 °C

2: sodium hydride / mineral oil / 1 h / 0 °C

3: sodium carbonate / triphenylphosphine; palladium diacetate / 1,4-dioxane; water / 0.5 h / 120 °C / Irradiation

With sodium hydride; sodium carbonate; N,N-diethylaniline; trichlorophosphate; palladium diacetate; triphenylphosphine; In 1,4-dioxane; water; mineral oil;

Reference yield:

: 79247-86-2
4-trifluoromethylthiazole-2-carboxylic acid ethyl ester

: 1251166-34-3
4-(4-methoxybenzyloxy)-6-(5-methylthiophen-2-yl)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium chloride; trimethylaluminum / toluene / 17 h / 0 - 80 °C

2.1: sodium ethanolate / ethanol / 24.5 h / 20 °C / Reflux

2.2: pH 5

3.1: N,N-diethylaniline; trichlorophosphate / 1 h / 0 - 100 °C

4.1: sodium hydride / mineral oil / 1 h / 0 °C

5.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,4-dioxane; water / 0.5 h / 120 °C / Irradiation

With trimethylaluminum; sodium ethanolate; sodium hydride; sodium carbonate; ammonium chloride; N,N-diethylaniline; trichlorophosphate; palladium diacetate; triphenylphosphine; In 1,4-dioxane; ethanol; water; toluene; mineral oil;