Ethyl (3-(2-(acetylamino)phenyl)-2-oxo-1(2H)-quinoxalinyl)acetate

Base Information

• Chemical Name: Ethyl (3-(2-(acetylamino)phenyl)-2-oxo-1(2H)-quinoxalinyl)acetate
• CAS No.: 53493-73-5
• Molecular Formula: C₂₀H₁₉N₃O₄
• Molecular Weight: 365.389
• NSC Number: 172628
• UNII: M3K7Z1Q9L0
• DSSTox Substance ID: DTXSID50201686
• Wikidata: Q83074891
• Mol file: 53493-73-5.mol

Synonyms:53493-73-5;Ethyl (3-(2-(acetylamino)phenyl)-2-oxo-1(2H)-quinoxalinyl)acetate;NSC172628;M3K7Z1Q9L0;NSC-172628;Ethyl 2-(3-(2-acetamidophenyl)-2-oxoquinoxalin-1(2H)-yl)acetate;ethyl 2-[3-(2-acetamidophenyl)-2-oxo-1,2-dihydroquinoxalin-1-yl]acetate;NSC 172628;UNII-M3K7Z1Q9L0;DTXSID50201686;HMS3456F03;ethyl 2-[3-(2-acetamidophenyl)-2-oxo-quinoxalin-1-yl]acetate;1(2H)-QUINOXALINEACETIC ACID, 3-(2-(ACETYLAMINO)PHENYL)-2-OXO-, ETHYL ESTER

Chemical Property of Ethyl (3-(2-(acetylamino)phenyl)-2-oxo-1(2H)-quinoxalinyl)acetate

Chemical Property:

• Density: 1.27g/cm³
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 365.13755610
• Heavy Atom Count: 27
• Complexity: 618

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CN1C2=CC=CC=C2N=C(C1=O)C3=CC=CC=C3NC(=O)C

Technology Process of Ethyl (3-(2-(acetylamino)phenyl)-2-oxo-1(2H)-quinoxalinyl)acetate

There total 3 articles about Ethyl (3-(2-(acetylamino)phenyl)-2-oxo-1(2H)-quinoxalinyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N-(2-(3-oxo-3,4-dihydroquinoxalin-2-yl)phenyl)acetamide (91658-85-4) + chloroacetic acid ethyl ester (105-39-5) → ethyl 2-(3-(2-acetamidophenyl)-2-oxoquinoxalin-1(2H)-yl)acetate (53493-73-5)

Guidance literature:

N-(2-(3-oxo-3,4-dihydroquinoxalin-2-yl)phenyl)acetamide; With potassium carbonate; N,N-dimethyl-formamide; In acetone; for 1h;

chloroacetic acid ethyl ester; In acetone; for 5h; Reflux;

DOI:10.1002/jhet.2896

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → ethyl 2-(3-(2-acetamidophenyl)-2-oxoquinoxalin-1(2H)-yl)acetate (53493-73-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 6 h / Reflux

2.1: N,N-dimethyl-formamide / 12 h / 20 °C

3.1: potassium carbonate; N,N-dimethyl-formamide / acetone / 1 h

3.2: 5 h / Reflux

With potassium carbonate; N,N-dimethyl-formamide; In N,N-dimethyl-formamide; acetone;

DOI:10.1002/jhet.2896

Reference yield:

1-acetyl-1H-indole-2,3-dione (574-17-4) → ethyl 2-(3-(2-acetamidophenyl)-2-oxoquinoxalin-1(2H)-yl)acetate (53493-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 12 h / 20 °C

2.1: potassium carbonate; N,N-dimethyl-formamide / acetone / 1 h

2.2: 5 h / Reflux

With potassium carbonate; N,N-dimethyl-formamide; In N,N-dimethyl-formamide; acetone;

DOI:10.1002/jhet.2896

upstream raw materials:

N-(2-(3-oxo-3,4-dihydroquinoxalin-2-yl)phenyl)acetamide

chloroacetic acid ethyl ester

indole-2,3-dione

1-acetyl-1H-indole-2,3-dione