(+)-tert-butyl 3-(2-oxo-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:(+)-tert-butyl 3-(2-oxo-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1402830-68-5
Molecular Formula:C₂₂H₂₅NO₃
Molecular Weight:351.445
Hs Code.:

Synonyms:(+)-tert-butyl 3-(2-oxo-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of (+)-tert-butyl 3-(2-oxo-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of (+)-tert-butyl 3-(2-oxo-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 4 articles about (+)-tert-butyl 3-(2-oxo-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 138350-86-4
N-(tert-butoxycarbonyl)-3-hydroxy-1,2,3,4-tetrahydroisoquinoline

: 98-86-2
acetophenone

: 1402830-68-5
(+)-tert-butyl 3-(2-oxo-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With (R)-DTBM-segphos; mesitylcopper(I); caesium carbonate; In tert-butyl methyl ether; at 50 ℃; for 48h; Reagent/catalyst; Temperature; Concentration; Time; enantioselective reaction; Molecular sieve;
DOI:10.1021/ja308872z DOI:10.1021/ja308872z

Reference yield:

: 1402830-72-1
C₁₄H₁₇NO₃

: 1402830-68-5
(+)-tert-butyl 3-(2-oxo-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

2: (R)-DTBM-segphos; mesitylcopper(I); caesium carbonate / tert-butyl methyl ether / 48 h / 50 °C / Molecular sieve

With (R)-DTBM-segphos; mesitylcopper(I); diisobutylaluminium hydride; caesium carbonate; In tetrahydrofuran; hexane; tert-butyl methyl ether;
DOI:10.1021/ja308872z DOI:10.1021/ja308872z

Reference yield:

: 615-13-4
2-indanone

: 1402830-68-5
(+)-tert-butyl 3-(2-oxo-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide; hydrogenchloride / water / 0 - 20 °C

2: dmap; triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

3: diisobutylaluminium hydride / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

4: (R)-DTBM-segphos; mesitylcopper(I); caesium carbonate / tert-butyl methyl ether / 48 h / 50 °C / Molecular sieve

With hydrogenchloride; dmap; sodium azide; (R)-DTBM-segphos; mesitylcopper(I); diisobutylaluminium hydride; caesium carbonate; triethylamine; In tetrahydrofuran; hexane; dichloromethane; tert-butyl methyl ether; water;
DOI:10.1021/ja308872z DOI:10.1021/ja308872z