N-Cyclohexyl-4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-nitro-phenoxy]-N-methyl-butyramide

Base Information

Chemical Name:N-Cyclohexyl-4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-nitro-phenoxy]-N-methyl-butyramide
CAS No.:105763-54-0
Molecular Formula:C₂₆H₂₉N₃O₆
Molecular Weight:479.533
Hs Code.:

Synonyms:N-Cyclohexyl-4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-nitro-phenoxy]-N-methyl-butyramide

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Chemical Property of N-Cyclohexyl-4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-nitro-phenoxy]-N-methyl-butyramide

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Technology Process of N-Cyclohexyl-4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-nitro-phenoxy]-N-methyl-butyramide

There total 8 articles about N-Cyclohexyl-4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-nitro-phenoxy]-N-methyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1074-82-4
potassium phtalimide

: 105763-53-9
4-(3-Bromomethyl-4-nitro-phenoxy)-N-cyclohexyl-N-methyl-butyramide

: 105763-54-0
N-Cyclohexyl-4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-nitro-phenoxy]-N-methyl-butyramide

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃;
DOI:10.1021/jm00385a011

Reference yield:

: 100-60-7
N-methylcyclohexylamine

: 105763-54-0
N-Cyclohexyl-4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-nitro-phenoxy]-N-methyl-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: aq. Na₂CO₃ / tetrahydrofuran / 1 h / Ambient temperature

2: 100 percent / NaBH₄ / ethanol / 1 h / Ambient temperature

3: Me₂N=CHBr⁽¹⁺⁾*Br^(1-) / dioxane / 0.5 h / Heating

4: 54 percent / dimethylformamide / 100 °C

With sodium tetrahydroborate; sodium carbonate; N-(bromomethylene)-N-methylmethanaminium bromide; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00385a011

Reference yield:

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 105763-54-0
N-Cyclohexyl-4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-nitro-phenoxy]-N-methyl-butyramide

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / K₂CO₃ / dimethylformamide / 1 h / 100 °C

2: 96 percent / aq. KOH / ethanol

3: oxalyl chloride / benzene; dimethylformamide / 1 h / Ambient temperature

4: aq. Na₂CO₃ / tetrahydrofuran / 1 h / Ambient temperature

5: 100 percent / NaBH₄ / ethanol / 1 h / Ambient temperature

6: Me₂N=CHBr⁽¹⁺⁾*Br^(1-) / dioxane / 0.5 h / Heating

7: 54 percent / dimethylformamide / 100 °C

With potassium hydroxide; sodium tetrahydroborate; oxalyl dichloride; sodium carbonate; N-(bromomethylene)-N-methylmethanaminium bromide; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00385a011