(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-[4-(methylthio)phenyl]propan-2-amine hydrochloride

Base Information

Chemical Name:(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-[4-(methylthio)phenyl]propan-2-amine hydrochloride
CAS No.:1028459-35-9
Molecular Formula:C₂₃H₂₂FN₃OS*ClH
Molecular Weight:443.973
Hs Code.:

Synonyms:(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-[4-(methylthio)phenyl]propan-2-amine hydrochloride

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Chemical Property of (1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-[4-(methylthio)phenyl]propan-2-amine hydrochloride

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Technology Process of (1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-[4-(methylthio)phenyl]propan-2-amine hydrochloride

There total 2 articles about (1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-[4-(methylthio)phenyl]propan-2-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1028459-72-4
(1R,2S)-2-amino-1-[4-(methylthio)phenyl]propan-1-ol

: 1-(fluorophenyl)-5-iodo-1H-indazole

: 1028459-35-9
(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-[4-(methylthio)phenyl]propan-2-amine hydrochloride

Guidance literature:: (1R,2S)-2-amino-1-[4-(methylthio)phenyl]propan-1-ol; 1-(fluorophenyl)-5-iodo-1H-indazole; With caesium carbonate; copper(l) iodide; In propyl cyanide; toluene; at 125 ℃; for 6h;

With hydrogenchloride; In isopropyl alcohol;

Reference yield: 25.0%

: 1028459-35-9
(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-[4-(methylthio)phenyl]propan-2-amine hydrochloride

Guidance literature:

Reference yield: 74.0%

: 383-63-1
ethyl trifluoroacetate,

: 1028459-35-9
(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-[4-(methylthio)phenyl]propan-2-amine hydrochloride

: 1034148-11-2
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methylsulfanylphenyl)propan-2-yl]acetamide

Guidance literature:: (1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-[4-(methylthio)phenyl]propan-2-amine hydrochloride; With N,N,N',N'-tetramethylguanidine; In methanol; for 0.0833333h;

ethyl trifluoroacetate,; In methanol; at 20 ℃; for 2.5h;