2-(((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-yl)amino)-2-oxoethyl acetate

Base Information

Chemical Name:2-(((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-yl)amino)-2-oxoethyl acetate
CAS No.:1034148-08-7
Molecular Formula:C₂₇H₂₆FN₃O₄S
Molecular Weight:507.586
Hs Code.:

Synonyms:2-(((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-yl)amino)-2-oxoethyl acetate

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Chemical Property of 2-(((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-yl)amino)-2-oxoethyl acetate

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Technology Process of 2-(((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-yl)amino)-2-oxoethyl acetate

There total 3 articles about 2-(((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-yl)amino)-2-oxoethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1028459-35-9
(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-[4-(methylthio)phenyl]propan-2-amine hydrochloride

: 13831-31-7
Acetoxyacetyl chloride

: 1034148-08-7
2-(((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-yl)amino)-2-oxoethyl acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1.25h;

Reference yield:

: 1028527-85-6
(1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-amine

: 13831-31-7
Acetoxyacetyl chloride

: 1034148-08-7
2-(((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-yl)amino)-2-oxoethyl acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.5h; Cooling with ice;
DOI:10.1016/j.bmcl.2016.10.052

Reference yield:

: 146137-76-0
2-Fluoro-5-iodo-benzaldehyde

: 1034148-08-7
2-(((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-yl)amino)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 20 - 150 °C

2: copper(l) iodide; caesium carbonate / 22 h / Inert atmosphere; Reflux

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice

With copper(l) iodide; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2016.10.052