1-O-[6'-(N-2'',2'',2''-trichloro-tert-butoxycarbonylamino)hexyl]-2-tetrahydropyranyl-sn-glycero-3-tosylate

Base Information

Chemical Name:1-O-[6'-(N-2'',2'',2''-trichloro-tert-butoxycarbonylamino)hexyl]-2-tetrahydropyranyl-sn-glycero-3-tosylate
CAS No.:257887-79-9
Molecular Formula:C₂₆H₄₀Cl₃NO₈S
Molecular Weight:633.031
Hs Code.:

Synonyms:1-O-[6'-(N-2'',2'',2''-trichloro-tert-butoxycarbonylamino)hexyl]-2-tetrahydropyranyl-sn-glycero-3-tosylate

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Chemical Property of 1-O-[6'-(N-2'',2'',2''-trichloro-tert-butoxycarbonylamino)hexyl]-2-tetrahydropyranyl-sn-glycero-3-tosylate

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Technology Process of 1-O-[6'-(N-2'',2'',2''-trichloro-tert-butoxycarbonylamino)hexyl]-2-tetrahydropyranyl-sn-glycero-3-tosylate

There total 4 articles about 1-O-[6'-(N-2'',2'',2''-trichloro-tert-butoxycarbonylamino)hexyl]-2-tetrahydropyranyl-sn-glycero-3-tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 257887-77-7
1-O-[6'-(N-2'',2'',2''-trichloro-tert-butoxycarbonylamino)hexyl]-sn-glyceryl-3-tosylate

: 257887-79-9
1-O-[6'-(N-2'',2'',2''-trichloro-tert-butoxycarbonylamino)hexyl]-2-tetrahydropyranyl-sn-glycero-3-tosylate

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1021/jo990739v

Reference yield:

: 66270-36-8
2,2,2-trichloro-1,1-dimethylethoxychloroformate

: 257887-79-9
1-O-[6'-(N-2'',2'',2''-trichloro-tert-butoxycarbonylamino)hexyl]-2-tetrahydropyranyl-sn-glycero-3-tosylate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / 4-(dimethylamino)pyridine / CHCl₃ / 24 h / 20 °C

2: 95 percent / BF₃*OEt₂ / CH₂Cl₂ / Heating

3: 95 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 20 h / 20 °C

With dmap; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; In dichloromethane; chloroform; 1: Acylation / 2: Ring cleavage / 3: Addition;
DOI:10.1021/jo990739v

Reference yield:

: 4048-33-3
6-amino-1-hexanol

: 257887-79-9
1-O-[6'-(N-2'',2'',2''-trichloro-tert-butoxycarbonylamino)hexyl]-2-tetrahydropyranyl-sn-glycero-3-tosylate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / 4-(dimethylamino)pyridine / CHCl₃ / 24 h / 20 °C

2: 95 percent / BF₃*OEt₂ / CH₂Cl₂ / Heating

3: 95 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 20 h / 20 °C

With dmap; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; In dichloromethane; chloroform; 1: Acylation / 2: Ring cleavage / 3: Addition;
DOI:10.1021/jo990739v