2-Methyl-4-[(4-methylphenyl)sulfonyl]quinoline

Base Information

Chemical Name:2-Methyl-4-[(4-methylphenyl)sulfonyl]quinoline
CAS No.:69722-30-1
Molecular Formula:C₁₇H₁₅NO₂S
Molecular Weight:297.378
Hs Code.:
DSSTox Substance ID:DTXSID501249999

Synonyms:2-Methyl-4-[(4-methylphenyl)sulfonyl]quinoline;DTXSID501249999;69722-30-1

Suppliers and Price of 2-Methyl-4-[(4-methylphenyl)sulfonyl]quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-Methyl-4-[(4-methylphenyl)sulfonyl]quinoline

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:297.08234989
Heavy Atom Count:21
Complexity:448

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)C2=CC(=NC3=CC=CC=C32)C

Technology Process of 2-Methyl-4-[(4-methylphenyl)sulfonyl]quinoline

There total 4 articles about 2-Methyl-4-[(4-methylphenyl)sulfonyl]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1076-28-4
2-methylquinoline N-oxide

: 824-79-3
sodium 4-methylbenzenesulfinate

: 69722-30-1
2-methyl-4-tosylquinoline

: 2-methyl-3-tosylquinoline

Guidance literature:: With tetrachloromethane; phosphonic acid diethyl ester; potassium hydroxide; In acetonitrile; at 70 ℃; for 24h;
DOI:10.1080/10426507.2017.1315422

Reference yield:

: 91-63-4
2-methylquinoline

: 69722-30-1
2-methyl-4-tosylquinoline

: 2-methyl-3-tosylquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; dihydrogen peroxide / water / 72 h / 70 °C

2: phosphonic acid diethyl ester; potassium hydroxide; tetrachloromethane / acetonitrile / 24 h / 70 °C

With tetrachloromethane; dihydrogen peroxide; acetic acid; phosphonic acid diethyl ester; potassium hydroxide; In water; acetonitrile; 2: |Atherton-Todd Synthesis;
DOI:10.1080/10426507.2017.1315422

Reference yield:

: 62-53-3
aniline

: 69722-30-1
2-methyl-4-tosylquinoline

: 2-methyl-3-tosylquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: 16 h / 25 °C

1.2: 12 h / 100 °C

2.1: acetic acid; dihydrogen peroxide / water / 72 h / 70 °C

3.1: phosphonic acid diethyl ester; potassium hydroxide; tetrachloromethane / acetonitrile / 24 h / 70 °C

With tetrachloromethane; dihydrogen peroxide; acetic acid; phosphonic acid diethyl ester; potassium hydroxide; In water; acetonitrile; 3.1: |Atherton-Todd Synthesis;
DOI:10.1080/10426507.2017.1315422