N-{3-[4-(2-tert-butoxycarbonylamino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

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Chemical Name:N-{3-[4-(2-tert-butoxycarbonylamino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid
CAS No.:383372-58-5
Molecular Formula:C₃₈H₃₂N₂O₁₀
Molecular Weight:676.679
Hs Code.:

<i>N</i>-{3-[4-(2-<i>tert</i>-butoxycarbonylamino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3<i>H</i>-xanthen-9-yl)-isophthalamic acid

Synonyms:N-{3-[4-(2-tert-butoxycarbonylamino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

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Chemical Property of N-{3-[4-(2-tert-butoxycarbonylamino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

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Technology Process of N-{3-[4-(2-tert-butoxycarbonylamino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

There total 3 articles about N-{3-[4-(2-tert-butoxycarbonylamino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 304449-84-1
5-carboxyfluorescein N-hydroxysuccinimide ester

: 260397-84-0
3-[4-(3-amino-prop-1-ynyl)-phenyl]-2-tert-butoxycarbonylamino-propionic acid

: 383372-58-5
N-{3-[4-(2-tert-butoxycarbonylamino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃;
DOI:10.1081/NCN-100002307

Reference yield:

: 103882-09-3,62129-44-6
N-Boc-4-I-Phe-OH

: 383372-58-5
N-{3-[4-(2-tert-butoxycarbonylamino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / CuI; Pd(PPh₃)4; Et₃N / dimethylformamide / 20 °C

2: 100 percent / aq. NH₄OH / 20 °C

3: 88 percent / DIEA / dimethylsulfoxide / 20 °C

With ammonium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Heck coupling reaction;
DOI:10.1081/NCN-100002307

Reference yield:

: 260397-83-9
2-tert-butoxycarbonylamino-3-{4-[3-(2,2,2-trifluoro-acetylamino)-prop-1-ynyl]-phenyl}-propionic acid

: 383372-58-5
N-{3-[4-(2-tert-butoxycarbonylamino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / aq. NH₄OH / 20 °C

2: 88 percent / DIEA / dimethylsulfoxide / 20 °C

With ammonium hydroxide; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide;
DOI:10.1081/NCN-100002307