tert-butyl (S)-2-(benzyl(1-methoxy-1-oxopropan-2-yl)carbamoyl)-2-(but-3-en-1-yl)hydrazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (S)-2-(benzyl(1-methoxy-1-oxopropan-2-yl)carbamoyl)-2-(but-3-en-1-yl)hydrazine-1-carboxylate
• CAS No.: 1640024-48-1
• Molecular Formula: C₂₁H₃₁N₃O₅
• Molecular Weight: 405.494
• Mol file: 1640024-48-1.mol

Synonyms:tert-butyl (S)-2-(benzyl(1-methoxy-1-oxopropan-2-yl)carbamoyl)-2-(but-3-en-1-yl)hydrazine-1-carboxylate

Chemical Property of tert-butyl (S)-2-(benzyl(1-methoxy-1-oxopropan-2-yl)carbamoyl)-2-(but-3-en-1-yl)hydrazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (S)-2-(benzyl(1-methoxy-1-oxopropan-2-yl)carbamoyl)-2-(but-3-en-1-yl)hydrazine-1-carboxylate

There total 4 articles about tert-butyl (S)-2-(benzyl(1-methoxy-1-oxopropan-2-yl)carbamoyl)-2-(but-3-en-1-yl)hydrazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

bis(trichloromethyl) carbonate (32315-10-9) + tert-butyl 2-(but-3-en-1-yl)hydrazine carboxylate (1620320-17-3) + (S)-N-benzyl-1-methoxy-1-oxopropan-2-aminium chloride (95071-12-8) → tert-butyl (S)-2-(benzyl(1-methoxy-1-oxopropan-2-yl)carbamoyl)-2-(but-3-en-1-yl)hydrazine-1-carboxylate (1640024-48-1)

Guidance literature:

bis(trichloromethyl) carbonate; (S)-N-benzyl-1-methoxy-1-oxopropan-2-aminium chloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;

tert-butyl 2-(but-3-en-1-yl)hydrazine carboxylate; In tetrahydrofuran; at 50 ℃; Inert atmosphere;

DOI:10.1039/c6ob01434h

Reference yield:

benzaldehyde (100-52-7) → tert-butyl (S)-2-(benzyl(1-methoxy-1-oxopropan-2-yl)carbamoyl)-2-(but-3-en-1-yl)hydrazine-1-carboxylate (1640024-48-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / methanol / 1.5 h / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 0.75 h / 0 - 20 °C / Inert atmosphere

2.2: 0.33 h / 0 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

3.2: 40 °C / Inert atmosphere

With sodium tetrahydroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;

DOI:10.1039/c4cc03660c

Reference yield:

2-(benzylidene-amino)-propionic acid methyl ester (53933-42-9,112674-72-3,120328-90-7,40216-71-5) → tert-butyl (S)-2-(benzyl(1-methoxy-1-oxopropan-2-yl)carbamoyl)-2-(but-3-en-1-yl)hydrazine-1-carboxylate (1640024-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol / 0.75 h / 0 - 20 °C / Inert atmosphere

1.2: 0.33 h / 0 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

2.2: 40 °C / Inert atmosphere

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;

DOI:10.1039/c4cc03660c

upstream raw materials:

benzaldehyde

2-(benzylidene-amino)-propionic acid methyl ester

bis(trichloromethyl) carbonate

tert-butyl 2-(but-3-en-1-yl)hydrazine carboxylate

Downstream raw materials:

(3S,6S)-2-benzyl-6-methoxy-3-methylhexahydro-1H-[1,2,4]triazino[1,2-a][1,2]diazepine-1,4(6H)-dione

(3S,6R)-2-benzyl-6-methoxy-3-methylhexahydro-1H-[1,2,4]triazino[1,2-a][1,2]diazepine-1,4(6H)-dione

(S)-2-benzyl-3-methyl-2,3,9,10-tetrahydro-8H-[1,2,4]triazino[1,2-a][1,2]diazepine-1,4-dione