2-phenyl-4'-(2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-carbonyl)benzanilide

Base Information

Chemical Name:2-phenyl-4'-(2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-carbonyl)benzanilide
CAS No.:159589-09-0
Molecular Formula:C₂₉H₂₅N₃O₂
Molecular Weight:447.536
Hs Code.:

Synonyms:2-phenyl-4'-(2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-carbonyl)benzanilide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-phenyl-4'-(2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-carbonyl)benzanilide

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Technology Process of 2-phenyl-4'-(2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-carbonyl)benzanilide

There total 4 articles about 2-phenyl-4'-(2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-carbonyl)benzanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 159589-08-9
1-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 947-84-2
2-Biphenylcarboxylic acid

: 159589-09-0
2-phenyl-4'-(2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-carbonyl)benzanilide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; for 120h; Ambient temperature;
DOI:10.1248/cpb.46.1566

Reference yield:

: 6516-89-8
2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 159589-09-0
2-phenyl-4'-(2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-carbonyl)benzanilide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 - 5 °C

2: 95 percent / H₂ / 10 percent Pd/C / acetic acid / 760 Torr / Ambient temperature

3: 42 percent / WSC, HOBt / dimethylformamide / 120 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.1566

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 159589-09-0
2-phenyl-4'-(2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-carbonyl)benzanilide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 - 5 °C

2: 95 percent / H₂ / 10 percent Pd/C / acetic acid / 760 Torr / Ambient temperature

3: 42 percent / WSC, HOBt / dimethylformamide / 120 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.1566